Coverage: 2020-01-01 onwards, with up to 300 results per query from PubMed and Europe PMC and separate limits on other sources. This is a selected index, not a complete literature search.
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Smith-Magenis Syndrome — Research Summary
Printed from RareWays (rareways.org) on 26 September 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Sleep–circadian dysfunction in Smith–Magenis syndrome: a systematic review and clinical framework for personalised management
Alejandro Lozano‐García et al. — Sleep and Biological Rhythms (24 August 2026)
https://doi.org/10.1007/s41105-026-00683-3
- 2.
Potential Contributions of Sleep and Circadian Rhythms to Behavioral Difficulties in Children with Smith-Magenis Syndrome in Real Life: An Actigraphy-Based Study.
Comajuan Marion et al. — Children (Basel, Switzerland) (24 July 2026)
https://pubmed.ncbi.nlm.nih.gov/42650327/
- 3.
CRISPR screening identifies TRIM27 as a destabilizer of the Smith-Magenis syndrome protein RAI1.
Lin Yu Cheng et al. — Genetics (6 July 2026)
https://pubmed.ncbi.nlm.nih.gov/42140622/
- 4.
Tirzepatide for weight and behavior management in a patient with Smith-Magenis syndrome.
Liao X Charlene et al. — JCEM case reports (1 July 2026)
https://pubmed.ncbi.nlm.nih.gov/42245471/
- 5.
From Behavioral and Sleep Disturbances to Genetic Diagnosis: Smith-Magenis Syndrome and the Importance of the Diagnostic Pathway.
Kılıçaslan Fethiye et al. — Developmental neurobiology (1 July 2026)
https://pubmed.ncbi.nlm.nih.gov/42396610/
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Smith-Magenis Syndrome
Smith-Magenis syndrome is a rare genetic condition caused by a missing piece of chromosome 17 or a change in the RAI1 gene. It typically involves intellectual disability, distinctive facial features, a disrupted sleep-wake cycle and challenging behaviours such as self-injury. Care is supportive and may include sleep management, early developmental therapies, behavioural support and regular medical review.
Most Recent Research
Common Questions
What is Smith-Magenis Syndrome?
Smith-Magenis syndrome is a rare genetic condition caused by a missing piece of chromosome 17 or a change in the RAI1 gene. It typically involves intellectual disability, distinctive facial features, a disrupted sleep-wake cycle and challenging behaviours such as self-injury. Care is supportive and may include sleep management, early developmental therapies, behavioural support and regular medical review.
How many clinical trials are available for Smith-Magenis Syndrome?
RareWays currently indexes 6 clinical trials for Smith-Magenis Syndrome. Trial availability changes as new studies are registered — check the trials tab for current status.
Where does the research data for Smith-Magenis Syndrome come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is refreshed automatically every day. All articles and trials link directly to their original sources.
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