Coverage: 2020-01-01 onwards, with up to 300 results per query from PubMed and Europe PMC and separate limits on other sources. This is a selected index, not a complete literature search.
Your saved research and appointment questionsView recorded trial and retraction changes
Phaeochromocytoma and Paraganglioma — Research Summary
Printed from RareWays (rareways.org) on 26 September 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Catecholamine-induced hypertensive crisis during laparoscopic adrenalectomy for pheochromocytoma.
Fatima Syeda Rukhsar et al. — Updates in surgery (22 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42771329/
- 2.
PTHrP-mediated hypercalcemia in metastatic adrenocortical carcinoma mimicking pheochromocytoma: a diagnostic challenge.
Kumari Kirshima et al. — Proceedings (Baylor University. Medical Center) (22 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42771717/
- 3.
Future scenarios of radioligand therapy in pheochromocytomas and paragangliomas.
Pacella S et al. (21 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42764321/
- 4.
Osteoporosis and Skeletal Fragility in non-Metastatic Pheochromocytomas and Paragangliomas: The Adrenergic-Skeletal Axis.
Vassallo Alberto et al. — Calcified tissue international (18 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42758342/
- 5.
Investigating the clinical utility of plasma succinate with insights from a Sdhb deficient murine model.
Cole Yasemin et al. — Endocrine-related cancer (18 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42758527/
Clinical Trials — Australian Sites
Ask your doctor whether you or your child may be eligible for any of these trials. Each has its ID and full eligibility criteria at the link shown.
- 1.
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
NCT04924075 — Recruiting — Phase 2 — Merck Sharp & Dohme LLC
Ages 12 and over
https://clinicaltrials.gov/study/NCT04924075
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Phaeochromocytoma and Paraganglioma
Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours of chromaffin cells, which make adrenaline and related hormones. A phaeochromocytoma grows in the adrenal gland; a paraganglioma grows in nerve tissue elsewhere, from the head and neck to the pelvis. Many release excess hormones that cause high blood pressure, headaches, palpitations and sweating. Up to 40% are linked to an inherited gene change, such as in the SDH genes, VHL, RET or NF1, so genetic testing is recommended for everyone diagnosed. Surgery is the main treatment; tumours that have spread are treated with targeted radionuclide therapy, chemotherapy and newer targeted drugs.
Most Recent Research
Common Questions
What is Phaeochromocytoma and Paraganglioma?
Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours of chromaffin cells, which make adrenaline and related hormones. A phaeochromocytoma grows in the adrenal gland; a paraganglioma grows in nerve tissue elsewhere, from the head and neck to the pelvis. Many release excess hormones that cause high blood pressure, headaches, palpitations and sweating. Up to 40% are linked to an inherited gene change, such as in the SDH genes, VHL, RET or NF1, so genetic testing is recommended for everyone diagnosed. Surgery is the main treatment; tumours that have spread are treated with targeted radionuclide therapy, chemotherapy and newer targeted drugs.
How many clinical trials are available for Phaeochromocytoma and Paraganglioma?
RareWays currently indexes 77 clinical trials for Phaeochromocytoma and Paraganglioma, of which 23 are actively recruiting. Trial availability changes as new studies are registered — check the trials tab for current status.
Where does the research data for Phaeochromocytoma and Paraganglioma come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is refreshed automatically every day. All articles and trials link directly to their original sources.
Get research updates
Monthly email when new findings are published for Phaeochromocytoma and Paraganglioma.
Your email and selected disease are stored for these updates. Unsubscribe any time. Privacy and deletion.
This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.