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Coverage: 2020-01-01 onwards, with up to 300 results per query from PubMed and Europe PMC and separate limits on other sources. This is a selected index, not a complete literature search.
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Pemphigus Vulgaris: Research Summary
Printed from RareWays (rareways.org)
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Skin and the eye: Ocular manifestations of common dermatological disorders: A narrative review with perspectives for Indian clinical practice
Amol Singh Garcha et al., International Journal of Ophthalmology Research (13 October 2026)
https://doi.org/10.33545/26181495.2026.v8.i3a.68
- 2.
Disease-specific and therapy-driven alterations in immunoglobulin G heavy-chain repertoire in peripheral blood mononuclear cells from pemphigus vulgaris and bullous pemphigoid patients.
Zhou Wenyu et al., Molecular immunology (13 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42868828/
- 3.
Nail involvement in pemphigus vulgaris: Insights from two cases
Naveen Kumar Kansal et al., Journal of Onychology and Nail Surgery (10 October 2026)
https://doi.org/10.25259/jons_15_2026
- 4.
Compuestos Fenólicos del Aceite de Oliva Extra Virgen como Componente Antiinflamatorio de la Dieta Mediterránea: Implicaciones Potenciales para el Pénfigo Vulgar
Tania Edith Martinez Aguilar et al., Revista Científica de Salud y Desarrollo Humano (8 October 2026)
https://doi.org/10.61368/r.s.d.h.v7i3.1152
- 5.
Targeted therapies in pemphigus vulgaris: Emerging horizons beyond rituximab.
Ahuja Rhea et al., Journal of the European Academy of Dermatology and Venereology : JEADV (6 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42836361/
Clinical Trials : Australian Sites
Ask your doctor whether you or your child may be eligible for any of these trials. Each has its ID and full eligibility criteria at the link shown.
- 1.
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod PH20 SC in Adults With Pemphigus (Vulgaris or Foliaceus)
NCT04598477 · TERMINATED · Phase 3 · argenx
Ages 18 and over
https://clinicaltrials.gov/study/NCT04598477
- 2.
A Study to Assess the Efficacy and Safety of a Subcutaneous Formulation of Efgartigimod PH20 SC in Adults With Pemphigus (Vulgaris or Foliaceus)
NCT04598451 · Completed · Phase 3 · argenx
Ages 18 and over
https://clinicaltrials.gov/study/NCT04598451
- 3.
A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris
NCT02704429 · Completed · Phase 2 · Principia Biopharma, a Sanofi Company
Ages 18 to 80
https://clinicaltrials.gov/study/NCT02704429
- 4.
A Study to Evaluate the Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil (MMF) in Participants With Pemphigus Vulgaris (PV)
NCT02383589 · Completed · Phase 3 · Hoffmann-La Roche
Ages 18 to 75
https://clinicaltrials.gov/study/NCT02383589
- 5.
Efficacy and Safety of Ofatumumab in Treatment of Pemphigus Vulgaris
NCT01920477 · TERMINATED · Phase 3 · Novartis Pharmaceuticals
Ages 18 to 70
https://clinicaltrials.gov/study/NCT01920477
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Pemphigus Vulgaris
Pemphigus vulgaris is a rare autoimmune disease in which the immune system attacks proteins that hold skin cells together. This causes painful blisters and erosions in the mouth and often on the skin. Treatment usually involves corticosteroids and other immune-suppressing medicines, including rituximab, to control the disease.
This overview is general information, not an individual medical assessment. Research is selected automatically and may include mismatches. How we select and explain research.
Most Recent Research
Background: The eye and the skin share embryological origin and immunological pathways, and a wide range of dermatological disorders produce recognisable ocular signs. Awareness of these associations allows earlier diagnosis and appropriately shared care between dermatologists and ophthalmologists. Purpose: To narratively review the ocular manifestations of four common dermatoses — psoriasis, atopic dermatitis, rosacea, and pemphigus vulgaris — and to place the available evidence in the context of Indian dermato-ophthalmic practice, where disease patterns, treatment access, and follow-up infrastructure differ from those in the Western literature this evidence base largely derives from. Methods: A narrative synthesis of the published literature (PubMed/MEDLINE-indexed reviews, systematic reviews, cohort studies, and Indian case series) on ocular involvement in psoriasis, atopic dermatitis, rosacea, and pemphigus vulgaris, supplemented by Indian dermato-ophthalmology outpatient studies where available. Findings: Across all four conditions, ocular surface inflammation — blepharitis, conjunctivitis, meibomian gland dysfunction, and dry eye disease — is the most frequently reported finding. More severe, sight-threatening involvement (keratitis, uveitis, cicatricial conjunctival disease) occurs less often but carries greater morbidity, particularly in rosacea keratitis and pemphigus-related cicatrisation. In atopic dermatitis, biologic therapy (dupilumab) has introduced a distinct iatrogenic conjunctivitis that must be distinguished from disease-driven ocular surface inflammation. Indian outpatient data suggest atopic dermatitis, herpes zoster ophthalmicus, and psoriasis are among the leading dermatology-referred causes of ocular morbidity seen in ophthalmology clinics. Conclusion: Ocular involvement in dermatological disease is common, frequently under-recognised, and often treatable. Structured referral pathways between dermatology and ophthalmology — feasible even within India's tertiary and district-hospital network — can reduce diagnostic delay and preventable ocular morbidity.
Common Questions
What is Pemphigus Vulgaris?
Pemphigus vulgaris is a rare autoimmune disease in which the immune system attacks proteins that hold skin cells together. This causes painful blisters and erosions in the mouth and often on the skin. Treatment usually involves corticosteroids and other immune-suppressing medicines, including rituximab, to control the disease.
How many clinical trials are available for Pemphigus Vulgaris?
RareWays currently indexes 35 clinical trials for Pemphigus Vulgaris, of which 4 are actively recruiting. These counts cover indexed trials across countries, not just your country. An Australian site does not necessarily mean that site is recruiting. Check locations, eligibility and current availability with the study team.
Where does the research data for Pemphigus Vulgaris come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is refreshed automatically every day. All articles and trials link directly to their original sources.
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