May-Thurner Syndrome — Research Summary
Printed from RareWays (rareways.com.au) on 18 September 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Clinical Characteristics and Impact of May-Thurner Syndrome in Patients With Proximal Deep Vein Thrombosis: Insights From the RIETE Registry.
Varona José F et al. — Angiology (1 October 2026)
https://pubmed.ncbi.nlm.nih.gov/41263573/
- 2.
Clinical manifestations, diagnosis, and therapeutic advances in May-Thurner Syndrome: A comprehensive literature review.
Ezekwueme Francis et al. — Current problems in cardiology (1 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42472601/
- 3.
From Negative Duplex to Phlegmasia in Minutes: Bedside POCUS Identifies Rapid Thrombosis Unmasking Underlying May-Thurner Syndrome.
Unger Anthony — Journal of clinical ultrasound : JCU (1 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42132364/
- 4.
Mechanical thrombectomy and venous-dedicated stent implantation for acute iliofemoral deep vein thrombosis with iliac vein compression.
Kobayashi Ayano et al. — Journal of cardiology cases (1 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42698602/
- 5.
Clinical treatment strategies and perioperative management of restenosis or secondary deep venous thrombosis after iliac vein balloon angioplasty.
Yang Zi-Shuo et al. — Phlebology (30 August 2026)
https://pubmed.ncbi.nlm.nih.gov/42669925/
Clinical Trials — Australian Sites
Ask your doctor whether you or your child may be eligible for any of these trials.
- 1.
BARD® The VENOVO™ Venous Stent Study for Treatment of Iliofemoral Occlusive Disease
Completed — Na — C. R. Bard
https://clinicaltrials.gov/study/NCT02655887
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
May-Thurner Syndrome
May-Thurner syndrome occurs when an artery in the pelvis presses on the left iliac vein, slowing blood flow out of the left leg. It can cause leg swelling, pain, varicose veins and a raised risk of deep vein thrombosis. Diagnosis usually involves ultrasound, CT or MR venography. Management may include blood-thinning medicines and procedures such as venous stenting.
Most Recent Research
May-Thurner syndrome (MTS) is an anatomical variant involving compression of the left iliac vein, predisposing to proximal deep vein thrombosis (DVT). Despite its clinical significance, population-level data remain limited. Using the RIETE (Registro Informatizado Enfermedad Trombo-Embólica) registry (2009-2024), we analyzed proximal DVT patients who underwent advanced imaging (CT-venography, contrast-venography, or MRI). Among 2872 patients with advanced imaging-confirmed proximal DVT, 124 (4.3%) had MTS. MTS patients were more likely to be female (78% vs 52%), younger (mean age 42 vs 62 years), and to present with left-sided DVT (92% vs 46%). They had fewer comorbidities, but greater exposure to estrogen or pregnancy. Endovascular therapy was more frequently used in MTS patients (44% vs 3.5%), who also received longer median anticoagulation (365 vs 164 days). Despite this, MTS patients had a significantly higher rate of recurrent DVT (rate ratio: 2.37; 95% CI 1.09-4.70). Multivariable analysis confirmed MTS as an independent predictor of recurrent DVT (adjusted hazard ratio: 2.26; 95% CI: 1.02-5.01). Major bleeding was non-significantly less frequent (rate ratio: 0.42; 95% CI: 0.13-1.04), though retroperitoneal bleeding was more common. MTS is underdiagnosed, has distinct clinical features and is associated with increased DVT recurrence despite aggressive therapy. Improved recognition and tailored management strategies are needed.
Common Questions
What is May-Thurner Syndrome?
May-Thurner syndrome occurs when an artery in the pelvis presses on the left iliac vein, slowing blood flow out of the left leg. It can cause leg swelling, pain, varicose veins and a raised risk of deep vein thrombosis. Diagnosis usually involves ultrasound, CT or MR venography. Management may include blood-thinning medicines and procedures such as venous stenting.
How many clinical trials are available for May-Thurner Syndrome?
RareWays currently indexes 11 clinical trials for May-Thurner Syndrome, of which 3 are actively recruiting. Trial availability changes as new studies are registered — check the trials tab for current status.
Where does the research data for May-Thurner Syndrome come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is updated regularly by Rocky, RareWays' automated research engine. All articles and trials link directly to their original sources.
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This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.