Fibrous Dysplasia/McCune-Albright Syndrome — Research Summary
Printed from RareWays (rareways.com.au) on 12 September 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Polyostotic Fibrous Dysplasia Mimicking Widespread Skeletal Metastases on 68 Ga-PSMA PET/CT and Demonstrating a Superscan Pattern on Bone Scintigraphy.
Baltacioglu Muhammet Halil et al. — Clinical nuclear medicine (1 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42257449/
- 2.
Polyostotic Fibrous Dysplasia in McCune–Albright Syndrome Presenting as a Discrete, GNAS-Positive Maxillary Mass Mimicking a Fibro-Osseous Neoplasm
Abigail McVicar et al. — Journal of Oral and Maxillofacial Surgery (1 September 2026)
https://doi.org/10.1016/j.joms.2026.06.183
- 3.
Impaired mitophagy contributes to osteogenesis and mineralization disorders in fibrous dysplasia.
Ling Ziji et al. — Autophagy (1 September 2026)
https://pubmed.ncbi.nlm.nih.gov/41803635/
- 4.
Individualized antiresorptive therapy in fibrous dysplasia and McCune-Albright syndrome: A retrospective cohort study.
Lipkow Tonio et al. — Bone reports (1 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42383208/
- 5.
Clinical features and treatment outcomes of fibrous dysplasia: a report from the Bone and Soft Tissue Tumor Registry in Japan.
Morishita Masayuki et al. — Japanese journal of clinical oncology (28 August 2026)
https://pubmed.ncbi.nlm.nih.gov/42664258/
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Fibrous Dysplasia/McCune-Albright Syndrome
Fibrous dysplasia is a rare bone condition where normal bone is replaced by scar-like fibrous tissue, causing pain, deformity and fractures. When it occurs together with café-au-lait skin patches and hormone problems such as early puberty, it is called McCune-Albright syndrome. Care focuses on protecting bone, managing pain and treating any hormone problems.
Most Recent Research
Fibrous dysplasia (FD) may demonstrate increased 68 Ga-PSMA uptake and mimic skeletal metastases in prostate cancer. We present a 63-year-old man with newly diagnosed prostate cancer who underwent 68 Ga-PSMA PET/CT for staging. Imaging revealed widespread skeletal uptake involving multiple regions, raising suspicion for diffuse metastatic disease. Bone scintigraphy demonstrated a superscan pattern. However, CT showed characteristic benign features, including ground-glass appearance, bone expansion, and preserved cortical integrity. Histopathologic examination confirmed fibrous dysplasia. This case highlights a potential diagnostic pitfall of 68 Ga-PSMA PET/CT and emphasizes the importance of correlating metabolic findings with CT morphology to avoid misinterpretation and overstaging.
Common Questions
What is Fibrous Dysplasia/McCune-Albright Syndrome?
Fibrous dysplasia is a rare bone condition where normal bone is replaced by scar-like fibrous tissue, causing pain, deformity and fractures. When it occurs together with café-au-lait skin patches and hormone problems such as early puberty, it is called McCune-Albright syndrome. Care focuses on protecting bone, managing pain and treating any hormone problems.
How many clinical trials are available for Fibrous Dysplasia/McCune-Albright Syndrome?
RareWays currently indexes 30 clinical trials for Fibrous Dysplasia/McCune-Albright Syndrome, of which 5 are actively recruiting. Trial availability changes as new studies are registered — check the trials tab for current status.
Where does the research data for Fibrous Dysplasia/McCune-Albright Syndrome come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is updated regularly by Rocky, RareWays' automated research engine. All articles and trials link directly to their original sources.
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This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.