RareWays is a research directory. It helps you understand the science. It is not medical advice. Always discuss your care options with your healthcare team.
Coverage: 2020-01-01 onwards, with up to 300 results per query from PubMed and Europe PMC and separate limits on other sources. This is a selected index, not a complete literature search.
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Dystonia: Research Summary
Printed from RareWays (rareways.org)
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Prefrontal and sensorimotor cortices showed opposite patterns of hemodynamic activity changes between eyes-open and eyes-closed conditions in blepharospasm
Xiao-Feng Huang et al., Frontiers in Aging Neuroscience (15 October 2026)
https://doi.org/10.3389/fnagi.2026.1825810
- 2.
Comparative study of brain perfusion network changes in blepharospasm and blepharospasm-oromandibular dystonia.
Wang Yanying et al., Brain research bulletin (15 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42628659/
- 3.
Motor coordination and behavioural deficits in a mouse model of KMT2B-related dystonia.
Harrer Philip et al., Neurobiology of disease (15 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42727616/
- 4.
Linguistically Informed Automated Estimates of Creak in Adductor Laryngeal Dystonia.
Fletcher Brittany N et al., Journal of speech, language, and hearing research : JSLHR (13 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42640843/
- 5.
Phenomenology in craniofacial movement disorders: a narrative review
Jamir Pitton Rissardo et al., The Egyptian Journal of Neurology Psychiatry and Neurosurgery (12 October 2026)
https://doi.org/10.1186/s41983-026-01257-3
Clinical Trials : Australian Sites
Ask your doctor whether you or your child may be eligible for any of these trials. Each has its ID and full eligibility criteria at the link shown.
- 1.
Study for Determine the Safety and Efficacy of Clostridium Botulinum Toxin Type A in Subjects With Cervical Dystonia
NCT01588574 · Completed · Phase 2 · Medy-Tox
Ages 18 to 75
https://clinicaltrials.gov/study/NCT01588574
- 2.
Study Comparing Short Term Efficacy of Dysport and Dysport NG to Placebo, and to Assess Efficacy and Safety of Dysport NG of Subjects With Cervical Dystonia
NCT01261611 · Completed · Phase 3 · Ipsen
Ages 18 and over
https://clinicaltrials.gov/study/NCT01261611
- 3.
Comparison of Efficacy and Safety of Two Different Types of Botulinum Toxin Type A in Moderate to Severe Cervical Dystonia
NCT00528541 · Completed · Phase 4 · Allergan
Ages 18 and over
https://clinicaltrials.gov/study/NCT00528541
- 4.
Efficacy and Safety of Two Different Botulinum Toxin Type A Treatments for Moderate to Severe Cervical Dystonia
NCT00432341 · TERMINATED · Phase 4 · Allergan
Ages 18 to 75
https://clinicaltrials.gov/study/NCT00432341
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Dystonia
Dystonia is a neurological movement disorder characterised by involuntary, sustained or repetitive muscle contractions causing twisting movements and abnormal postures. It is estimated to affect around 7,500 Australians. Dystonia can be focal (affecting one body part) or generalised, and may be primary or secondary to another condition.
This overview is general information, not an individual medical assessment. Research is selected automatically and may include mismatches. How we select and explain research.
Most Recent Research
Background Blepharospasm (BSP), characterized by involuntary eyelid closure and difficulty opening the eyes, often results in functional blindness. However, there is a lack of objective and quantitative diagnostic markers, and the differences in hemodynamics between eyes-open (EO) and eyes-closed (EC) conditions are unknown in BSP. Objective To address this issue, we utilized functional near-infrared spectroscopy (fNIRS) to measure the oxygenation differences in the prefrontal cortex (PFC) and sensorimotor cortex in response to EO and EC conditions and compared them with those of healthy controls. Methods We analyzed data from 96 BSP individuals and 31 healthy controls (HCs) by using the amplitude of low-frequency fluctuations (ALFF) determined by functional near-infrared spectroscopy (derived from fNIRS) to measure the oxygenation differences in the prefrontal cortex (PFC) and sensorimotor cortex in response to EO and EC conditions. Results The BSP group and the HC group exhibited opposite patterns of differences between the EC and EO conditions. In the HC group, the ALFF was greater in the EC condition than in the EO condition in the frontopolar area (FPA) and orbitofrontal cortex and lower in the EC condition than in the EO condition in the bilateral sensorimotor cortex. In the BSP group, the ALFF was greater in the EC condition than the EO condition in the bilateral sensorimotor cortex and lower in the EC condition than in the EO condition in the frontopolar area and bilateral dorsolateral prefrontal cortex. Moreover, differences in the EC-EO patterns at channel 44 and channel 3 between the two groups showed promising excellent discrimination potential, pending external validation. Conclusion The BSP group and the HCs group showed opposite patterns of EO-EC differences in the prefrontal cortex and sensorimotor cortex. The delta EO-EC difference between the right S2 and the right FPA showed promising has excellent differential diagnostic value for BSP in this discovery cohort and is a candidate and is expected to become an early diagnostic biomarker requiring external validation and neuromodulation therapeutic target.
Common Questions
What is Dystonia?
Dystonia is a neurological movement disorder characterised by involuntary, sustained or repetitive muscle contractions causing twisting movements and abnormal postures. It is estimated to affect around 7,500 Australians. Dystonia can be focal (affecting one body part) or generalised, and may be primary or secondary to another condition.
How many clinical trials are available for Dystonia?
RareWays currently indexes 212 clinical trials for Dystonia, of which 33 are actively recruiting. These counts cover indexed trials across countries, not just your country. An Australian site does not necessarily mean that site is recruiting. Check locations, eligibility and current availability with the study team.
Where does the research data for Dystonia come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is refreshed automatically every day. All articles and trials link directly to their original sources.
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