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Coverage: 2020-01-01 onwards, with up to 300 results per query from PubMed and Europe PMC and separate limits on other sources. This is a selected index, not a complete literature search.
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Complex Regional Pain Syndrome: Research Summary
Printed from RareWays (rareways.org)
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Comparison between Cervical Epidural and Stellate Ganglion Block in Management of Complex Regional Pain Syndrome of the Upper Limb: A Prospective Comparative Study
, International Journal of Drug Delivery Technology (16 October 2026)
https://doi.org/10.25258/ijddt.16.72s.44
- 2.
Painful arthroplasty with disproportionate pain: Recognition and management of complex regional pain syndrome
Stephanie O’Palko et al., World Journal of Orthopedics (12 October 2026)
https://doi.org/10.5312/wjo.126605
- 3.
Chronic complex regional pain syndrome patient IgM has pronociceptive effects in the spinal cord, but not skin, of fracture mice
Tian‐Zhi Guo et al., Research Square (9 October 2026)
https://doi.org/10.21203/rs.3.rs-11099287/v1
- 4.
Atraumatic Shoulder-Hand Syndrome Presenting as Complex Regional Pain Syndrome Type 1 in an 81-Year-Old Patient With Diabetes Mellitus
Francisco M Torres, Cureus (8 October 2026)
https://doi.org/10.7759/cureus.117644
- 5.
Ehlers-Danlos syndrome and complex regional pain syndrome: counting codes versus counting disease?
Thomas Mason A et al., Regional anesthesia and pain medicine (6 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42838611/
Clinical Trials : Australian Sites
Ask your doctor whether you or your child may be eligible for any of these trials. Each has its ID and full eligibility criteria at the link shown.
- 1.
Efficacy and Safety of Intravenous Neridronic Acid in CRPS
NCT03530345 · TERMINATED · Phase 3 · Grünenthal GmbH
Ages 18 and over
https://clinicaltrials.gov/study/NCT03530345
- 2.
CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1
NCT02504008 · UNKNOWN · Phase 3 · Axsome Therapeutics, Inc.
Ages 18 and over
https://clinicaltrials.gov/study/NCT02504008
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Complex Regional Pain Syndrome
Complex regional pain syndrome is a rare condition that causes long-lasting, severe pain in a limb, usually after an injury, surgery or fracture. The pain is out of proportion to the original injury and may come with swelling, skin colour and temperature changes, and stiffness. Treatment usually combines physiotherapy, pain medicines, and psychological support, and early care is encouraged.
This overview is general information, not an individual medical assessment. Research is selected automatically and may include mismatches. How we select and explain research.
Most Recent Research
Complex Regional Pain Syndrome (CRPS) is a neuropathic pain syndrome resulting from complex pathophysiological mechanisms affecting multiple levels of the nervous system.This work aimed to evaluate two regimens (cervical epidural block and stellate ganglion block) efficacy of treatment in easing chronic refractory pain in cases had upper limb CRPS after orthopedic trauma.Prospective comparative study included 90 patients with upper limb CRPS admitted to Pain Clinic, Tanta University Hospitals.The cases were divided into 2 equal groups: Group 1: Ultrasound (U/S) guided stellate ganglion block and group 2: C-arm guided unilateral cervical epidural block.Brief Pain Inventory short form was significantly decreased immediately after injection, at 3 and 6 months than baseline BPISF in both group 1 (from 8 (7-9) at baseline to 1 (0-2) at 6 months) and group 2 (from 8 (7-8) at baseline to 1 (0-1) at 6 months) (P.value <0.05).BPI-SF was insignificantly different at baseline, immediately after injection, at 3 and 6 months between both groups.Pregabalin total dose was significantly decreased at 3 and 6 months than baseline dose in group 1 and group 2 (P<0.05).There was an no significant difference between both groups regarding pregabalin total dose at baseline, 3 months, and 6 months.Both cervical epidural block and stellate ganglion block are safe and effective for pain control in upper limb CRPS, with no significant difference between techniques.
Common Questions
What is Complex Regional Pain Syndrome?
Complex regional pain syndrome is a rare condition that causes long-lasting, severe pain in a limb, usually after an injury, surgery or fracture. The pain is out of proportion to the original injury and may come with swelling, skin colour and temperature changes, and stiffness. Treatment usually combines physiotherapy, pain medicines, and psychological support, and early care is encouraged.
How many clinical trials are available for Complex Regional Pain Syndrome?
RareWays currently indexes 163 clinical trials for Complex Regional Pain Syndrome, of which 23 are actively recruiting. These counts cover indexed trials across countries, not just your country. An Australian site does not necessarily mean that site is recruiting. Check locations, eligibility and current availability with the study team.
Where does the research data for Complex Regional Pain Syndrome come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is refreshed automatically every day. All articles and trials link directly to their original sources.
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