RareWays is a research directory. It helps you understand the science. It is not medical advice. Always discuss your care options with your healthcare team.
Coverage: 2020-01-01 onwards, with up to 300 results per query from PubMed and Europe PMC and separate limits on other sources. This is a selected index, not a complete literature search.
Updates are delayed or unverified. Check original sources for the latest information.
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CADASIL: Research Summary
Printed from RareWays (rareways.org)
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Neurologists Urged to Consider CADASIL Diagnosis Instead of MS
Dan Hurley, Neurology Today (15 October 2026)
https://doi.org/10.1097/01.wnt.0001288812.05008.4b
- 2.
From asymptomatic carriers to CADASIL: context-dependent phenotypic variability of the NOTCH3 p.Arg1231Cys variant across three European cohorts and potential implications of LDL cholesterol
Teresa Nutile et al., medRxiv (6 October 2026)
https://doi.org/10.64898/2026.10.03.26364647
- 3.
Multimodal characterization of age-dependent neurovascular phenotypes in Notch3
Yang Junting et al., Brain research bulletin (1 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42462891/
- 4.
Multiple Sclerosis Misdiagnosis in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: A Genotype-Misphenotype Study.
Mendis Dinith D et al., Neurology. Genetics (1 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42689243/
- 5.
Spontaneous intracerebral hemorrhage as initial manifestation of CADASIL with a p.Arg578Cys variant in the exon 11 of NOTCH3.
Rosa-Batlle I et al., Neurologia (1 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42762848/
Clinical Trials : Australian Sites
Ask your doctor whether you or your child may be eligible for any of these trials. Each has its ID and full eligibility criteria at the link shown.
- 1.
The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment
NCT00103948 · Completed · Phase 2 · Eisai Limited
Ages 25 to 70
https://clinicaltrials.gov/study/NCT00103948
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
CADASIL
CADASIL is an inherited condition that damages the small blood vessels in the brain, caused by changes in the NOTCH3 gene. It can cause migraine with aura, strokes, mood changes and, over time, problems with thinking and memory, usually starting in adulthood. There is no specific treatment yet, so care focuses on lowering stroke risk and managing symptoms.
This overview is general information, not an individual medical assessment. Research is selected automatically and may include mismatches. How we select and explain research.
Most Recent Research
Common Questions
What is CADASIL?
CADASIL is an inherited condition that damages the small blood vessels in the brain, caused by changes in the NOTCH3 gene. It can cause migraine with aura, strokes, mood changes and, over time, problems with thinking and memory, usually starting in adulthood. There is no specific treatment yet, so care focuses on lowering stroke risk and managing symptoms.
How many clinical trials are available for CADASIL?
RareWays currently indexes 10 clinical trials for CADASIL, of which 1 is actively recruiting. These counts cover indexed trials across countries, not just your country. An Australian site does not necessarily mean that site is recruiting. Check locations, eligibility and current availability with the study team.
Where does the research data for CADASIL come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is refreshed automatically every day. All articles and trials link directly to their original sources.
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This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.