Arachnoiditis — Research Summary
Printed from RareWays (rareways.com.au) on 24 September 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Subarachnoid-subarachnoid Bypass for Refractory Cases of Adhesive Syringomyelia.
Sakurada Kokyo et al. — Neurologia medico-chirurgica (9 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42716762/
- 2.
Idiopathic Spinal Arachnoiditis Presenting With Acute Bilateral Lower Extremity Weakness
Hakan Ak et al. — Journal of Current Surgery (29 August 2026)
https://doi.org/10.14740/jcs1027
- 3.
Clinicopathologic features of spinal arachnoiditis in patients with surgically treated syringomyelia: A retrospective study of 60 cases.
Choi Joseph Y et al. — Journal of neuropathology and experimental neurology (27 August 2026)
https://pubmed.ncbi.nlm.nih.gov/42658566/
- 4.
Retraction notice to "Quantitative proteomic landscape of the pathophysiology of adhesive arachnoiditis and its clinical significance: Structure and mechanism of TNC and RANBP1 proteins" [Int. J. Biol. Macromol. 287 (2025) 138444].
Zhang Weikang et al. — International journal of biological macromolecules (12 August 2026)
https://pubmed.ncbi.nlm.nih.gov/42586843/
- 5.
Pathogenesis of Adhesive Arachnoiditis: Risk Factors Inciting Events, Viral Reactivation, Inflammation
Forest Tennant DrPH, MPH, MD (1 July 2026)
https://doi.org/10.64611/xanz9910
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Arachnoiditis
Arachnoiditis is inflammation of the arachnoid membrane, one of the layers surrounding the spinal cord and nerve roots. Scarring can make the nerve roots stick together, causing burning or stinging pain, numbness, tingling and bladder or bowel problems. It may follow spinal surgery, injection procedures, injury or infection. Care focuses on pain management, physiotherapy and support for daily function.
Most Recent Research
BACKGROUND: Syringomyelia, secondary to adhesive arachnoiditis, is an intractable disease characterized by progressive extension cranially and caudally, resulting in severe neurological deficits. Subarachnoid-subarachnoid bypass has recently been reported for syringomyelia from trauma or spinal tumor surgery. METHODS: We investigated whether subarachnoid-subarachnoid bypass is a salvage treatment for refractory adhesive arachnoiditis of various etiologies, including arachnoid abnormality and hemorrhage. Patients who underwent subarachnoid-subarachnoid bypass between 2021 and 2025 for recurrent adhesive syringomyelia after conventional treatments were retrospectively reviewed. The primary outcome was the change in syrinx length from baseline to follow-up. Secondary outcomes included neurological outcomes and surgical complications. RESULTS: Six patients (median age 55 years; 2 men) were included. Patients had undergone a median of 2.5 conventional treatments, such as arachnoidolysis or intradural shunt placement, before subarachnoid-subarachnoid bypass. The syrinx showed temporary regression followed by re-expansion in all cases, attributed to extensive adhesions. Two patients presented with upper extremity paresis and pain, two with paraparesis, and two with severe paresthesia of the body trunk and lower extremities. After subarachnoid-subarachnoid bypass, the syrinx length showed a significant overall reduction (median, preoperative vs. postoperative: 9.5 vs. 5.0 levels; p = 0.014) in the median follow-up of 36 months. Neurological symptoms improved in five patients. Two patients were complicated with tube occlusion, which resolved with re-operation. CONCLUSIONS: Subarachnoid-subarachnoid bypass may be an effective option for refractory cases of syringomyelia not only from trauma or spinal tumor surgery but also from adhesive arachnoiditis due to arachnoid abnormality and hemorrhage.
Common Questions
What is Arachnoiditis?
Arachnoiditis is inflammation of the arachnoid membrane, one of the layers surrounding the spinal cord and nerve roots. Scarring can make the nerve roots stick together, causing burning or stinging pain, numbness, tingling and bladder or bowel problems. It may follow spinal surgery, injection procedures, injury or infection. Care focuses on pain management, physiotherapy and support for daily function.
How many clinical trials are available for Arachnoiditis?
RareWays currently indexes 2 clinical trials for Arachnoiditis, of which 1 is actively recruiting. Trial availability changes as new studies are registered — check the trials tab for current status.
Where does the research data for Arachnoiditis come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is updated regularly by Rocky, RareWays' automated research engine. All articles and trials link directly to their original sources.
Get research updates
Monthly email when new findings are published for Arachnoiditis.
No spam. Unsubscribe any time. Not medical advice.
This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.