Wilson Disease — Research Summary
Printed from RareWays (rareways.com.au) on 10 June 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Risk Factors for Postoperative Complications After Splenectomy in Wilson's Disease: A 986-Patient Single-Center Cohort Study.
Shi Xiuquan et al. — Journal of investigative surgery : the official journal of the Academy of Surgical Research (1 December 2026)
https://pubmed.ncbi.nlm.nih.gov/41657263/
- 2.
Interval saccades and fronto-parietal-occipital connectivity: Neural signatures of cognitive-sensorimotor impairment in Wilson's disease.
Yang Caiyu et al. — Behavioural brain research (8 May 2026)
https://pubmed.ncbi.nlm.nih.gov/41692374/
- 3.
A powerful agonist for metal ion interference therapy: Multiple programs of cell death to amplify tumor metalloimmunotherapy.
Huang Yechen et al. — Biomaterials (1 May 2026)
https://pubmed.ncbi.nlm.nih.gov/41365036/
- 4.
Copper in Human Health and Disease: Insights from Inherited Disorders.
Petruzzelli Raffaella et al. — Physiology (Bethesda, Md.) (1 May 2026)
https://pubmed.ncbi.nlm.nih.gov/41213165/
- 5.
Choreiform Wilson's disease and a distinctive 7-Tesla magnetic resonance imaging finding.
Santana Ana Rosa et al. — Arquivos de neuro-psiquiatria (1 April 2026)
https://pubmed.ncbi.nlm.nih.gov/41871576/
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Wilson Disease
Wilson disease is a genetic condition where copper accumulates in the liver, brain, and other organs due to a faulty ATP7B gene. If untreated it causes liver failure and neurological problems. Early detection and lifelong copper-chelation therapy can prevent serious complications and allow a near-normal life.
Most Recent Research
INTRODUCTION: Splenectomy is commonly performed in Wilson's disease patients with hypersplenism secondary to portal hypertension, yet large-scale data on postoperative complications remain scarce. METHODS: A retrospective analysis was conducted on 986 Wilson's disease patients who underwent splenectomy between 2001 and 2019. RESULTS: The overall postoperative complication rate was 68.7%, with bleeding, fever, and portal vein thrombosis occurring in 29.0%, 44.9%, and 20.5% of cases, respectively. Multivariable analysis identified hypersplenism grade as an independent risk factor for postoperative bleeding, abnormal liver function for postoperative fever, and lower alanine aminotransferase and albumin levels for portal vein thrombosis. DISCUSSION: These findings suggest that preoperative evaluation of hypersplenism severity, liver function, and key laboratory markers can aid in surgical risk stratification and optimize perioperative management for Wilson's disease patients undergoing splenectomy.
Common Questions
What is Wilson Disease?
Wilson disease is a genetic condition where copper accumulates in the liver, brain, and other organs due to a faulty ATP7B gene. If untreated it causes liver failure and neurological problems. Early detection and lifelong copper-chelation therapy can prevent serious complications and allow a near-normal life.
How many clinical trials are available for Wilson Disease?
RareWays currently indexes 63 clinical trials for Wilson Disease, of which 18 are actively recruiting. Trial availability changes as new studies are registered — check the trials tab for current status.
Where does the research data for Wilson Disease come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is updated regularly by Rocky, RareWays' automated research engine. All articles and trials link directly to their original sources.
Get research updates
Monthly email when new findings are published for Wilson Disease.
No spam. Unsubscribe any time. Not medical advice.
This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.