Wilson Disease — Research Summary
Printed from RareWays (rareways.com.au) on 5 April 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Risk Factors for Postoperative Complications After Splenectomy in Wilson's Disease: A 986-Patient Single-Center Cohort Study.
Shi Xiuquan et al. — Journal of investigative surgery : the official journal of the Academy of Surgical Research (1 December 2026)
https://pubmed.ncbi.nlm.nih.gov/41657263/
- 2.
Interval saccades and fronto-parietal-occipital connectivity: Neural signatures of cognitive-sensorimotor impairment in Wilson's disease.
Yang Caiyu et al. — Behavioural brain research (8 May 2026)
https://pubmed.ncbi.nlm.nih.gov/41692374/
- 3.
A powerful agonist for metal ion interference therapy: Multiple programs of cell death to amplify tumor metalloimmunotherapy.
Huang Yechen et al. — Biomaterials (1 May 2026)
https://pubmed.ncbi.nlm.nih.gov/41365036/
- 4.
Copper in Human Health and Disease: Insights from Inherited Disorders.
Petruzzelli Raffaella et al. — Physiology (Bethesda, Md.) (1 May 2026)
https://pubmed.ncbi.nlm.nih.gov/41213165/
- 5.
Choreiform Wilson's disease and a distinctive 7-Tesla magnetic resonance imaging finding.
Santana Ana Rosa et al. — Arquivos de neuro-psiquiatria (1 April 2026)
https://pubmed.ncbi.nlm.nih.gov/41871576/
Clinical Trials — Currently Recruiting (Australia)
Ask your doctor whether you or your child may be eligible for any of these trials.
- 1.
Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
Recruiting — Phase 3 — University College, London
https://clinicaltrials.gov/study/NCT04685616
- 2.
Zenith LAA Occlusion System
Recruiting — Na — AuriGen Medical Ltd
https://clinicaltrials.gov/study/NCT05951101
- 3.
Five PLus Year EffIcacy of Endoscopic Sleeve Gastroplasty (ESG) for Sustained WeigHT Loss
Recruiting — Boston Scientific Corporation
https://clinicaltrials.gov/study/NCT06894498
- 4.
Subthreshold Nanosecond Laser for Non-resolving Central Serous Chorioretinopathy
Recruiting — Na — Nova Eye Medical Pty Ltd.
https://clinicaltrials.gov/study/NCT05570591
- 5.
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Recruiting — Phase 3 — Cybin IRL Limited
https://clinicaltrials.gov/study/NCT06793397
- 6.
A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma.
Recruiting — Phase 3 — Epizyme, Inc.
https://clinicaltrials.gov/study/NCT04224493
- 7.
A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT
Recruiting — Phase 2 — Children's Oncology Group
https://clinicaltrials.gov/study/NCT04684368
- 8.
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
Recruiting — Phase 3 — United Therapeutics
https://clinicaltrials.gov/study/NCT05943535
- 9.
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
Recruiting — Phase 3 — Pfizer
https://clinicaltrials.gov/study/NCT06758401
- 10.
A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.
Recruiting — Phase 1 — Nimbus Wadjet, Inc.
https://clinicaltrials.gov/study/NCT06898450
- 11.
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
Recruiting — Phase 3 — Eli Lilly and Company
https://clinicaltrials.gov/study/NCT07174336
- 12.
A Study of Brenipatide in Adult Participants With Major Depressive Disorder
Recruiting — Phase 3 — Eli Lilly and Company
https://clinicaltrials.gov/study/NCT07412756
- 13.
A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
Recruiting — Phase 3 — Bellus Health Inc. - a GSK company
https://clinicaltrials.gov/study/NCT05600777
- 14.
Staphylococcus Aureus Network Adaptive Platform Trial
Recruiting — Phase 4 — University of Melbourne
https://clinicaltrials.gov/study/NCT05137119
- 15.
Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment
Recruiting — Phase 3 — Boehringer Ingelheim
https://clinicaltrials.gov/study/NCT06151574
- 16.
A Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobulin A (IgA) Nephropathy at High Risk of Progression
Recruiting — Phase 3 — Hoffmann-La Roche
https://clinicaltrials.gov/study/NCT05797610
- 17.
The National Australian HCV Point-of-Care Testing Program
Recruiting — Kirby Institute
https://clinicaltrials.gov/study/NCT05042544
- 18.
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma
Recruiting — Phase 2 — Children's Oncology Group
https://clinicaltrials.gov/study/NCT06368817
- 19.
JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer
Recruiting — Phase 3 — University of Texas Southwestern Medical Center
https://clinicaltrials.gov/study/NCT02468024
- 20.
Rigicon Infla10® Three-Piece Inflatable Penile Prosthesis (ERASE ED)
Recruiting — Na — Rigicon, Inc.
https://clinicaltrials.gov/study/NCT05574868
- 21.
A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer
Recruiting — Phase 3 — Verastem, Inc.
https://clinicaltrials.gov/study/NCT06072781
- 22.
Microbial Restoration in Inflammatory Bowel Diseases
Recruiting — Phase 1 — St Vincent's Hospital Melbourne
https://clinicaltrials.gov/study/NCT04970446
- 23.
Platform of Randomized Adaptive Clinical Trials in Critical Illness
Recruiting — Na — University Health Network, Toronto
https://clinicaltrials.gov/study/NCT05440851
- 24.
TrialNet Pathway to Prevention of T1D
Recruiting — University of South Florida
https://clinicaltrials.gov/study/NCT00097292
- 25.
A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
Recruiting — Phase 3 — Inventiva Pharma
https://clinicaltrials.gov/study/NCT04849728
- 26.
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
Recruiting — Phase 3 — Janssen Research & Development, LLC
https://clinicaltrials.gov/study/NCT07276399
- 27.
A Study of Elritercept Alone or Together With Ruxolitinib in Adults With Myelofibrosis
Recruiting — Phase 2 — Takeda
https://clinicaltrials.gov/study/NCT05037760
- 28.
A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
Recruiting — Phase 1 — DualityBio Inc.
https://clinicaltrials.gov/study/NCT05150691
- 29.
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
Recruiting — Na — Melanoma and Skin Cancer Trials Limited
https://clinicaltrials.gov/study/NCT03860883
- 30.
A Study to Determine the Efficacy and Safety of Tividenofusp Alfa (DNL310) vs Idursulfase in Pediatric and Young Adult Participants With Neuronopathic (nMPS II) or Non-Neuronopathic Mucopolysaccharidosis Type II (nnMPS II)
Recruiting — Phase 2 — Denali Therapeutics Inc.
https://clinicaltrials.gov/study/NCT05371613
- 31.
A Study of JSB462 (Luxdegalutamide) Plus Lutetium (177Lu) Vipivotide Tetraxetan in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)
Recruiting — Phase 2 — Novartis Pharmaceuticals
https://clinicaltrials.gov/study/NCT07047118
- 32.
Testing the Addition of an Immunotherapy Drug, Cemiplimab (REGN2810), Plus Surgery to the Usual Surgery Alone for Treating Advanced Skin Cancer
Recruiting — Phase 3 — National Cancer Institute (NCI)
https://clinicaltrials.gov/study/NCT06568172
- 33.
Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
Recruiting — Phase 3 — Novartis Pharmaceuticals
https://clinicaltrials.gov/study/NCT05827081
- 34.
Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib
Recruiting — Phase 3 — Kartos Therapeutics, Inc.
https://clinicaltrials.gov/study/NCT06479135
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Wilson Disease
Wilson disease is a genetic condition where copper accumulates in the liver, brain, and other organs due to a faulty ATP7B gene. If untreated it causes liver failure and neurological problems. Early detection and lifelong copper-chelation therapy can prevent serious complications and allow a near-normal life.
Most Recent Research
INTRODUCTION: Splenectomy is commonly performed in Wilson's disease patients with hypersplenism secondary to portal hypertension, yet large-scale data on postoperative complications remain scarce. METHODS: A retrospective analysis was conducted on 986 Wilson's disease patients who underwent splenectomy between 2001 and 2019. RESULTS: The overall postoperative complication rate was 68.7%, with bleeding, fever, and portal vein thrombosis occurring in 29.0%, 44.9%, and 20.5% of cases, respectively. Multivariable analysis identified hypersplenism grade as an independent risk factor for postoperative bleeding, abnormal liver function for postoperative fever, and lower alanine aminotransferase and albumin levels for portal vein thrombosis. DISCUSSION: These findings suggest that preoperative evaluation of hypersplenism severity, liver function, and key laboratory markers can aid in surgical risk stratification and optimize perioperative management for Wilson's disease patients undergoing splenectomy.
This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.