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Coverage: 2020-01-01 onwards, with up to 300 results per query from PubMed and Europe PMC and separate limits on other sources. This is a selected index, not a complete literature search.
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Stiff Person Spectrum Disorder: Research Summary
Printed from RareWays (rareways.org)
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Under what conditions can rituximab treatment be considered for patients with stiff person syndrome?
Tripdatabase, Zenodo (CERN European Organization for Nuclear Research) (15 October 2026)
https://doi.org/10.5281/zenodo.23396317
- 2.
ID# 2201943 SEVERE PAIN AND SPASMS IN PARANEOPLASTIC STIFF PERSON SYNDROME WITH LEPTOMENINGEAL SPREAD: A MULTIDISCIPLINARY APPROACH
Sydney Smith et al., Neuromodulation Technology at the Neural Interface (1 October 2026)
https://doi.org/10.1016/j.neurom.2026.06.394
- 3.
Stiff-person syndrome and systemic lupus erythematosus: A cross-disease examination of autoimmunity and neurological involvement
Umer Shahid et al., Current Journal of Neurology (20 September 2026)
https://doi.org/10.18502/cjn.v24i4.22686
- 4.
Stiff-person syndrome mimicking ankylosing spondylitis
Shiva Prasad et al., Internet Journal of Rheumatology and Clinical Immunology (18 September 2026)
https://doi.org/10.15305/ijrci/v14i1/358
- 5.
Exteroceptive Reflex Myoclonus Triggered by Distal Nerve Stimulation in Anti-GAD65 Stiff-Person Syndrome.
Sim Jingwei et al., Movement disorders clinical practice (1 September 2026)
https://pubmed.ncbi.nlm.nih.gov/41878800/
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Stiff Person Spectrum Disorder
Stiff Person Spectrum Disorder is a rare autoimmune neurological condition causing progressive muscle rigidity, painful spasms, and heightened sensitivity to stimuli. It is associated with antibodies against glutamic acid decarboxylase (GAD65) in the majority of cases. Misdiagnosis is common due to its unusual presentation. Treatment includes diazepam, baclofen, and immunotherapy.
This overview is general information, not an individual medical assessment. Research is selected automatically and may include mismatches. How we select and explain research.
Most Recent Research
Rituximab may be considered for stiff person syndrome patients refractory to conventional treatments like IVIG, though evidence is limited, and efficacy appears variable. Further research is necessary to establish clear guidelines and identify patient subgroups most likely to benefit.
Common Questions
What is Stiff Person Spectrum Disorder?
Stiff Person Spectrum Disorder is a rare autoimmune neurological condition causing progressive muscle rigidity, painful spasms, and heightened sensitivity to stimuli. It is associated with antibodies against glutamic acid decarboxylase (GAD65) in the majority of cases. Misdiagnosis is common due to its unusual presentation. Treatment includes diazepam, baclofen, and immunotherapy.
How many clinical trials are available for Stiff Person Spectrum Disorder?
RareWays currently indexes 13 clinical trials for Stiff Person Spectrum Disorder, of which 1 is actively recruiting. These counts cover indexed trials across countries, not just your country. An Australian site does not necessarily mean that site is recruiting. Check locations, eligibility and current availability with the study team.
Where does the research data for Stiff Person Spectrum Disorder come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is refreshed automatically every day. All articles and trials link directly to their original sources.
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