Spinocerebellar Ataxia — Research Summary
Printed from RareWays (rareways.com.au) on 26 July 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Discovery of a mutation-containing circRNA in polyglutamine disease through systematic analysis of RNAs with CAG repeats.
Pawlik Weronika et al. — RNA biology (1 December 2026)
https://pubmed.ncbi.nlm.nih.gov/42340810/
- 2.
Regenerative potential of muse cells in ROS-mediated cardiac injury: An in vitro oxygen-glucose deprivation/reoxygenation model.
Sallam Abeer et al. — Life sciences (15 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42214608/
- 3.
Electrostatic control of membrane disruption and amorphous coaggregation by dynorphin A variants.
Habibnia Mohsen et al. — Biochemical and biophysical research communications (20 August 2026)
https://pubmed.ncbi.nlm.nih.gov/42235331/
- 4.
White matter structural network alterations in spinocerebellar ataxia type 3: A graph theory analysis.
Wang Qiannan et al. — Neuroscience (17 August 2026)
https://pubmed.ncbi.nlm.nih.gov/42191105/
- 5.
Synergistic construction of heat-stable resistant starch by confined Retrogradation of short-chain amylose within calcium alginate beads.
Li Mingju et al. — Food chemistry (15 August 2026)
https://pubmed.ncbi.nlm.nih.gov/42208430/
Clinical Trials — Currently Recruiting (Australia)
Ask your doctor whether you or your child may be eligible for any of these trials.
- 1.
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Recruiting — Sanford Health
https://clinicaltrials.gov/study/NCT01793168
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Spinocerebellar Ataxia
Spinocerebellar Ataxia refers to a group of inherited progressive neurological disorders characterised by degeneration of the cerebellum and its connections, causing difficulty walking, poor coordination, and speech problems. More than 40 genetic subtypes have been identified. There is currently no disease-modifying treatment, but active clinical trials are under way.
Most Recent Research
CAG repeat tracts occur in both non-coding and translated RNAs, have tended to lengthen throughout evolution, and are thought to enhance neuronal function. We identified over 600 human RNAs (including mRNAs, lncRNAs, and circRNAs) with at least 10 CAG repeats, originating from 58 genomic loci, which vary, e.g. in the rate of CAG length polymorphism. Several circRNAs originate from the ATXN7 locus, where CAG expansion causes spinocerebellar ataxia type 7 (SCA7). For selected circATXN7(3,4).1 (circ1), we demonstrated its cytoplasmic localization, as well as its presence in 40S, monosome and polysome fractions. We showed that circ1 is expressed in human fibroblasts, blood and cerebellum, and, importantly, we identified a mutation-containing circRNA with potential implications in SCA7.
Common Questions
What is Spinocerebellar Ataxia?
Spinocerebellar Ataxia refers to a group of inherited progressive neurological disorders characterised by degeneration of the cerebellum and its connections, causing difficulty walking, poor coordination, and speech problems. More than 40 genetic subtypes have been identified. There is currently no disease-modifying treatment, but active clinical trials are under way.
How many clinical trials are available for Spinocerebellar Ataxia?
RareWays currently indexes 85 clinical trials for Spinocerebellar Ataxia, of which 17 are actively recruiting. Trial availability changes as new studies are registered — check the trials tab for current status.
Where does the research data for Spinocerebellar Ataxia come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is updated regularly by Rocky, RareWays' automated research engine. All articles and trials link directly to their original sources.
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This information is for general awareness only.
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