Spinocerebellar Ataxia — Research Summary
Printed from RareWays (rareways.com.au) on 5 April 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Densification pretreatment using ternary phenolic DES enables efficient biomass fractionation and selective lignin arylation modification.
Yuan Xinchuan et al. — Bioresource technology (1 June 2026)
https://pubmed.ncbi.nlm.nih.gov/41819351/
- 2.
Performance, carcass traits and meat quality of lambs fed sugarcane silage (Saccharum officinarum) with or without Tithonia diversifolia.
Marques Natana Mendes et al. — Meat science (1 June 2026)
https://pubmed.ncbi.nlm.nih.gov/41723907/
- 3.
Effects of different exercise modalities on four major neurodegenerative diseases and their molecular mechanisms.
Wang Shuo et al. — Neuroscience (7 May 2026)
https://pubmed.ncbi.nlm.nih.gov/41796789/
- 4.
Metformin improves RAN protein pathology, alternative splicing, and behavioral phenotypes in SCA8 mice.
Romano Lisa El et al. — Life science alliance (1 May 2026)
https://pubmed.ncbi.nlm.nih.gov/41771688/
- 5.
Novel dipotassium oxalate-containing mouth rinses for the prevention of erosive tooth wear.
Scontre Luiza Santos et al. — Journal of dentistry (1 May 2026)
https://pubmed.ncbi.nlm.nih.gov/41765223/
Clinical Trials — Currently Recruiting (Australia)
Ask your doctor whether you or your child may be eligible for any of these trials.
- 1.
PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury
Recruiting — Phase 3 — The George Institute
https://clinicaltrials.gov/study/NCT06819592
- 2.
International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry
Recruiting — SCAD Alliance
https://clinicaltrials.gov/study/NCT04496687
- 3.
The EXCEL Registry of Patients Requiring ECMO
Recruiting — Australian and New Zealand Intensive Care Research Centre
https://clinicaltrials.gov/study/NCT03793257
- 4.
CRICKET: Critical Events in Anaesthetised Kids Undergoing Tracheal Intubation
Recruiting — Thomas Riva
https://clinicaltrials.gov/study/NCT05804188
- 5.
ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients
Recruiting — Phase 3 — Australian and New Zealand Intensive Care Research Centre
https://clinicaltrials.gov/study/NCT04588311
- 6.
Platform of Randomized Adaptive Clinical Trials in Critical Illness
Recruiting — Na — University Health Network, Toronto
https://clinicaltrials.gov/study/NCT05440851
- 7.
Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia
Recruiting — Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
https://clinicaltrials.gov/study/NCT06166706
- 8.
A Pivotal Study of N-Acetyl-L-Leucine on Niemann-Pick Disease Type C
Recruiting — Phase 3 — IntraBio Inc
https://clinicaltrials.gov/study/NCT05163288
- 9.
A Multiple Ascending Dose Study of DT-216P2 in Patients With Friedreich's Ataxia
Recruiting — Phase 1 — Design Therapeutics, Inc.
https://clinicaltrials.gov/study/NCT06874010
- 10.
Red Blood Cell Transfusion in ECMO - A Feasibility Trial
Recruiting — Na — Australian and New Zealand Intensive Care Research Centre
https://clinicaltrials.gov/study/NCT05814094
- 11.
Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial
Recruiting — Phase 3 — Monash University
https://clinicaltrials.gov/study/NCT05072314
- 12.
The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study
Recruiting — Na — University of Leicester
https://clinicaltrials.gov/study/NCT04204915
- 13.
BonE and Joint Infections - Simplifying Treatment in Children Trial
Recruiting — Phase 4 — Murdoch Childrens Research Institute
https://clinicaltrials.gov/study/NCT04538053
- 14.
Quality of Pediatric Resuscitation in a Multicenter Collaborative
Recruiting — Children's Hospital of Philadelphia
https://clinicaltrials.gov/study/NCT02708134
- 15.
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease (NPC)
Recruiting — Phase 3 — Azafaros A.G.
https://clinicaltrials.gov/study/NCT07082725
- 16.
Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation
Recruiting — Na — Region Skane
https://clinicaltrials.gov/study/NCT05564754
- 17.
Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator (ICD) Implantation to Prevent Tachyarrhythmias Following Acute Myocardial Infarction (PROTECT-ICD)
Recruiting — Na — Western Sydney Local Health District
https://clinicaltrials.gov/study/NCT03588286
- 18.
End-Tidal Oxygen for Intubation in the Emergency Department
Recruiting — Na — Sydney Local Health District
https://clinicaltrials.gov/study/NCT06578468
- 19.
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Recruiting — Sanford Health
https://clinicaltrials.gov/study/NCT01793168
- 20.
EXtubation Related Complications - the EXTUBE Study (EXTUBE)
Recruiting — University Health Network, Toronto
https://clinicaltrials.gov/study/NCT06442930
- 21.
Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study
Recruiting — Friedreich's Ataxia Research Alliance
https://clinicaltrials.gov/study/NCT06016946
- 22.
Primary Tumor Research and Outcomes Network
Recruiting — AO Innovation Translation Center
https://clinicaltrials.gov/study/NCT02790983
- 23.
SEALion: Study on Supplemental Oxygenation Via Nasal Cannula for Young Children During Intubation
Recruiting — Na — Vinícius C Quintão, MD, MSc, PhD
https://clinicaltrials.gov/study/NCT06683599
- 24.
A Study to Learn More About the Effects and Long-Term Safety of BIIB141 (Omaveloxolone) in Participants With Friedreich's Ataxia Aged 2 to 15 Years Old (BRAVE)
Recruiting — Phase 3 — Biogen
https://clinicaltrials.gov/study/NCT06953583
- 25.
Study of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2
Recruiting — Phase 1 — Arrowhead Pharmaceuticals
https://clinicaltrials.gov/study/NCT06672445
- 26.
COLchicine and Non-enteric Coated Aspirin in the Cardiovascular Outcomes Trial of Patients With Type 2 Diabetes
Recruiting — Phase 3 — Montreal Heart Institute
https://clinicaltrials.gov/study/NCT05633810
- 27.
Stepcare Extended Follow-up Substudy
Recruiting — Na — Region Skane
https://clinicaltrials.gov/study/NCT06207942
- 28.
HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial
Recruiting — Na — Population Health Research Institute
https://clinicaltrials.gov/study/NCT04743765
- 29.
Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)
Recruiting — Na — University of Michigan
https://clinicaltrials.gov/study/NCT05376267
- 30.
International CRDS Registry
Recruiting — Population Health Research Institute
https://clinicaltrials.gov/study/NCT06508164
- 31.
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of GM1 Gangliosidosis or GM2 Gangliosidosis
Recruiting — Phase 3 — Azafaros A.G.
https://clinicaltrials.gov/study/NCT07082543
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Spinocerebellar Ataxia
Spinocerebellar Ataxia refers to a group of inherited progressive neurological disorders characterised by degeneration of the cerebellum and its connections, causing difficulty walking, poor coordination, and speech problems. More than 40 genetic subtypes have been identified. There is currently no disease-modifying treatment, but active clinical trials are under way.
Most Recent Research
Acid deep eutectic solvent (DES)-mediated delignification causes much polysaccharide (especially xylan) degradation, compromising biomass upgrading efficiency. To tackle this issue, a ternary DES densification pretreatment (betaine-guaiacol-salicylic acid, BE-GUA-SCA) was developed, enabling efficient lignin removal and high sugar retention, yielding 73.1% delignification with preservation of 98% glucan and 85% xylan under optimal conditions. Guaiacol spontaneously polymerized with Cα in lignin's β-aryl ether during pretreatment, forming a guaiacolated structure that blocked undesirable condensation. The resulting arylated lignin enriched phenolic hydroxyls and retained β-aryl ethers. Moreover, this ternary DES system showed excellent recyclability (94.42% DES recovery and 96.19% DES purity after 5 cycles) and superior functional stability (>70% delignification, over 90% glucan recovery and 80% xylan recovery after 5 cycles), overcoming traditional acidic catalysis limitations and offering a novel strategy for selective lignin functionalization and polyphenol derivative synthesis.
This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.