Prader-Willi Syndrome — Research Summary
Printed from RareWays (rareways.com.au) on 26 July 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
The diameter of malformation capillaries does not influence the efficacy of photodynamic therapy for facial port-wine stains: a pilot study.
Hao Limin et al. — The Journal of dermatological treatment (1 December 2026)
https://pubmed.ncbi.nlm.nih.gov/42267614/
- 2.
Cylindrospermopsin induces progressive myocardial injury via disrupting sympathetic β-adrenergic pathway and redox homeostasis: A molecular, radiological, and histopathological evaluation.
Al-Aream Maha A et al. — Toxicon : official journal of the International Society on Toxinology (15 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42142633/
- 3.
Coherent multi-transducer ultrasound imaging using diverging waves.
Dryburgh Paul et al. — Ultrasonics (1 August 2026)
https://pubmed.ncbi.nlm.nih.gov/41747485/
- 4.
Magel2 deficiency promotes cardiac remodeling and increases arrhythmogenic susceptibility in a mouse model relevant to Prader-Willi and Schaaf-Yang syndromes.
Dötsch Laura et al. — Clinical science (London, England : 1979) (15 July 2026)
https://pubmed.ncbi.nlm.nih.gov/42275194/
- 5.
Correlations between endocrine-metabolic characteristics and body fat distribution, appetite, growth, and memory in children with Prader-Willi syndrome.
Zhang Ying et al. — Clinics (Sao Paulo, Brazil) (2 July 2026)
https://pubmed.ncbi.nlm.nih.gov/42391657/
Clinical Trials — Currently Recruiting (Australia)
Ask your doctor whether you or your child may be eligible for any of these trials.
- 1.
A Study of Pitolisant in Patients With Prader-Willi Syndrome
Recruiting — Phase 3 — Harmony Biosciences Management, Inc.
https://clinicaltrials.gov/study/NCT06366464
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Prader-Willi Syndrome
Prader-Willi syndrome is a complex genetic condition caused by loss of function of genes on chromosome 15. It causes hyperphagia (insatiable hunger), intellectual disability, and hormonal problems. Without strict dietary management, obesity and its complications are a major risk. Growth hormone therapy has been transformative.
Most Recent Research
BACKGROUND: Photodynamic therapy (PDT) is an effective treatment for port-wine stains (PWS). However, the relationship between the diameter of malformed capillaries and the efficacy of PDT in PWS has been rarely studied. OBJECTIVE: This study aimed to investigate the relationship between the diameter of malformed capillaries and the efficacy of PDT in PWS. METHODS: Dermoscopy and capillaroscopy images were obtained before the first treatment to assess the capillary patterns and diameters of malformation capillaries in PWS, respectively. VISIA images were captured before treatment and two months after the second PDT session to evaluate treatment efficacy. RESULTS: Forty-seven patients were included in this study. Univariate analysis indicated that lesion location, prior treatment history, and capillary pattern influenced the outcomes of facial PWS after two PDT sessions. However, no significant differences were observed among patients with varying capillary diameters. Logistic regression analysis confirmed that capillary pattern and lesion location were significant factors affecting the efficacy of PDT, whereas capillary diameter was not. CONCLUSION: In this study, no significant correlation was observed between the responses of facial PWS to PDT and the varying vascular diameters. However, a significant correlation was observed between PDT efficacy and the capillary pattern or lesion location.
Common Questions
What is Prader-Willi Syndrome?
Prader-Willi syndrome is a complex genetic condition caused by loss of function of genes on chromosome 15. It causes hyperphagia (insatiable hunger), intellectual disability, and hormonal problems. Without strict dietary management, obesity and its complications are a major risk. Growth hormone therapy has been transformative.
How many clinical trials are available for Prader-Willi Syndrome?
RareWays currently indexes 111 clinical trials for Prader-Willi Syndrome, of which 17 are actively recruiting. Trial availability changes as new studies are registered — check the trials tab for current status.
Where does the research data for Prader-Willi Syndrome come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is updated regularly by Rocky, RareWays' automated research engine. All articles and trials link directly to their original sources.
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This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.