RareWays is a research directory. It helps you understand the science. It is not medical advice. Always discuss your care options with your healthcare team.
Coverage: 2020-01-01 onwards, with up to 300 results per query from PubMed and Europe PMC and separate limits on other sources. This is a selected index, not a complete literature search.
Updates are delayed or unverified. Check original sources for the latest information.
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Osteosarcoma: Research Summary
Printed from RareWays (rareways.org)
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Expression of Concern: MicroRNA-93 promotes the tumorigenesis of osteosarcoma by targeting TIMP2.
Zhang Hua et al., Bioscience reports (21 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42751804/
- 2.
Retraction Note: C-X-C chemokine receptor family genes in osteosarcoma: expression profiles, regulatory networks, and functional impact on tumor progression.
Dong Siqi et al., Hereditas (17 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42892675/
- 3.
Periplocin suppresses osteosarcoma progression by triggering necroptosis and pyroptosis through the “4EBP1-eIF4E” pathway
Jianwei Sun et al., Biology Direct (16 October 2026)
https://doi.org/10.1186/s13062-026-01021-w
- 4.
Surgical management of spinal and sacral osteosarcoma: a retrospective single-institution case series.
Khalilullah Taha et al., Journal of neurosurgery. Spine (16 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42887035/
- 5.
Exosomal CircRNA_102619–miR-330-3p Interaction Regulates Osteosarcoma Progression and Metastasis by Forming the Lung Pre-Metastatic Niche
Ming‐Yu Lien et al., International Journal of Molecular Sciences (16 October 2026)
https://doi.org/10.3390/ijms27209193
Clinical Trials : Australian Sites
Ask your doctor whether you or your child may be eligible for any of these trials. Each has its ID and full eligibility criteria at the link shown.
- 1.
A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma
NCT05691478 · SUSPENDED · Phase 2 / Phase 3 · National Cancer Institute (NCI)
Up to age 40
https://clinicaltrials.gov/study/NCT05691478
- 2.
Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
NCT05235165 · Recruiting · Phase 3 · Children's Oncology Group
Up to age 50
https://clinicaltrials.gov/study/NCT05235165
- 3.
Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial
NCT04320888 · Active (not recruiting) · Phase 2 · National Cancer Institute (NCI)
Ages 12 Months to 21
https://clinicaltrials.gov/study/NCT04320888
- 4.
Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)
NCT04195555 · Active (not recruiting) · Phase 2 · National Cancer Institute (NCI)
Ages 12 Months to 21
https://clinicaltrials.gov/study/NCT04195555
- 5.
A Study to Compare the Efficacy and Safety of Ifosfamide and Etoposide With or Without Lenvatinib in Children, Adolescents and Young Adults With Relapsed and Refractory Osteosarcoma
NCT04154189 · Completed · Phase 2 · Eisai Inc.
Ages 2 to 25
https://clinicaltrials.gov/study/NCT04154189
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Osteosarcoma
Osteosarcoma is a rare cancer that starts in the bone, most often in the long bones around the knee or shoulder, and it most commonly affects teenagers and young adults. Early signs can include bone pain and swelling. Treatment usually combines chemotherapy with surgery to remove the tumour, and research continues into better drug combinations and limb-sparing surgery.
This overview is general information, not an individual medical assessment. Research is selected automatically and may include mismatches. How we select and explain research.
Most Recent Research
Common Questions
What is Osteosarcoma?
Osteosarcoma is a rare cancer that starts in the bone, most often in the long bones around the knee or shoulder, and it most commonly affects teenagers and young adults. Early signs can include bone pain and swelling. Treatment usually combines chemotherapy with surgery to remove the tumour, and research continues into better drug combinations and limb-sparing surgery.
How many clinical trials are available for Osteosarcoma?
RareWays currently indexes 322 clinical trials for Osteosarcoma, of which 63 are actively recruiting. These counts cover indexed trials across countries, not just your country. An Australian site does not necessarily mean that site is recruiting. Check locations, eligibility and current availability with the study team.
Where does the research data for Osteosarcoma come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is refreshed automatically every day. All articles and trials link directly to their original sources.
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