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Coverage: 2020-01-01 onwards, with up to 300 results per query from PubMed and Europe PMC and separate limits on other sources. This is a selected index, not a complete literature search.
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Necrotising Enterocolitis: Research Summary
Printed from RareWays (rareways.org)
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Association of Red Blood Transfusion With Necrotizing Enterocolitis in Very Low Birth-Weight Neonates: A 7-Year Retrospective Cohort Study in Saudi Arabia.
Al-Wassia Heidi et al., Advances in neonatal care : official journal of the National Association of Neonatal Nurses (19 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42896071/
- 2.
Exploring the impact of spontaneous intestinal perforation and necrotizing enterocolitis treatment modality on shunt outcomes in premature infants.
Chandler Katherine et al., Journal of neurosurgery. Pediatrics (16 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42887031/
- 3.
Role of pyroptosis-related hub genes in necrotizing enterocolitis: a study based on bioinformatics analysis and clinical cohort validation.
Li Yihui et al., International immunopharmacology (16 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42887046/
- 4.
Serum Olink proteomics-based exploration of novel predictive biomarkers for necrotizing enterocolitis
Yu Dai et al., iScience (15 October 2026)
https://doi.org/10.1016/j.isci.2026.117617
- 5.
Portal Venous Gas in Necrotizing Enterocolitis: Association with Disease Severity and Clinical Outcomes
Ilaria Acquaviva et al., Preprints.org (15 October 2026)
https://doi.org/10.20944/preprints202610.1525.v1
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Necrotising Enterocolitis
Necrotising enterocolitis is a serious bowel condition that mainly affects newborn babies, especially those born very early or with a low birth weight. Parts of the bowel wall become inflamed and damaged, causing feeding problems, a swollen tummy and illness that can come on quickly. Care involves stopping feeds, antibiotics and intensive support, with surgery needed in some babies.
This overview is general information, not an individual medical assessment. Research is selected automatically and may include mismatches. How we select and explain research.
Most Recent Research
BACKGROUND: Necrotizing enterocolitis (NEC) is a multifactorial disorder of the gastrointestinal tract of very low birth-weight (VLBW) infants. Blood transfusions are suspected to be associated with NEC in this population. PURPOSE: To examine the association between packed red blood cells (PRBCs) transfusion and NEC in VLBW neonates (less than 1500 gm) or less than 32 weeks. METHODS: A retrospective cohort study of all VLBW neonates admitted to the neonatal intensive care unit (NICU) at King Abdulaziz University Hospital (KAUH) from January 1, 2014, to December 31, 2020. RESULTS: Of 3018 newborns admitted to the NICU, 441 were VLBW neonates born at less than 32 weeks of gestational age (mean: 29 weeks ± 2.3; male: 220, 49.9%). The sample was divided into 2 groups: those who developed NEC 49 (11.1%) and those who did not develop NEC 392 (88.9%). Infants who developed NEC had significantly lower birth weight, gestational age (GA), and initial hematocrit (P < 0.05). Although blood transfusions were more often noted in those who developed NEC 7.4% versus 32.1% (P < 0.01), only sepsis showed significant associations with NEC, OR 8.2 (3.893-17.259) after adjusting for other studied risk factors. IMPLICATION FOR PRACTICE AND RESEARCH: PRBC transfusion was not associated with an increased risk of NEC in VLBW neonates. Sepsis was the only variable found to be significantly associated with NEC. Future prospective cohort studies to assess the role of anemia, the timing of PRBC transfusion, and the number of transfusions on incidence of NEC are needed.
Common Questions
What is Necrotising Enterocolitis?
Necrotising enterocolitis is a serious bowel condition that mainly affects newborn babies, especially those born very early or with a low birth weight. Parts of the bowel wall become inflamed and damaged, causing feeding problems, a swollen tummy and illness that can come on quickly. Care involves stopping feeds, antibiotics and intensive support, with surgery needed in some babies.
How many clinical trials are available for Necrotising Enterocolitis?
RareWays currently indexes 111 clinical trials for Necrotising Enterocolitis, of which 7 are actively recruiting. These counts cover indexed trials across countries, not just your country. An Australian site does not necessarily mean that site is recruiting. Check locations, eligibility and current availability with the study team.
Where does the research data for Necrotising Enterocolitis come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is refreshed automatically every day. All articles and trials link directly to their original sources.
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