RareWays is a research directory. It helps you understand the science. It is not medical advice. Always discuss your care options with your healthcare team.
Coverage: 2020-01-01 onwards, with up to 300 results per query from PubMed and Europe PMC and separate limits on other sources. This is a selected index, not a complete literature search.
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Narcolepsy: Research Summary
Printed from RareWays (rareways.org)
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
A Novel Disease-Modifying Strategy for Narcolepsy Type 1 Preclinical Rationale and Development Roadmap for the DOXA Platform: Integrated Orexin Restoration and Translational Neuroprotective Development
Éric Konofal et al. (17 October 2026)
https://doi.org/10.13140/rg.2.2.26468.33923
- 2.
Establishment of a reference interval for cerebrospinal fluid Orexin-A in children and its diagnostic cutoff value for narcolepsy
Ruiyan Wang et al., Pakistan Journal of Medical Sciences (16 October 2026)
https://doi.org/10.12669/pjms.42.11.20072
- 3.
Psychometric properties of the novel patient-reported Functional Impacts of Narcolepsy Instrument (FINI) using data from phase 3 clinical trials in narcolepsy type 1
Heather Romero et al., Frontiers in Neurology (15 October 2026)
https://doi.org/10.3389/fneur.2026.1884901
- 4.
Symptom improvement with dosing above 9 g of low-sodium oxybate: effectiveness and safety in participants with narcolepsy in the DUET study.
Simmons Jerald H et al., Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine (15 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42881322/
- 5.
Hypocretin-1/orexin-A fragment1-16 as a potential surrogate marker for diagnosing narcolepsy type 1.
Wenz Elena S et al., Sleep (13 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42139087/
Clinical Trials : Currently Recruiting (Australia)
Ask your doctor whether you or your child may be eligible for any of these trials. Each has its ID and full eligibility criteria at the link shown.
- 1.
A Study of TAK-360 in People With Narcolepsy or Idiopathic Hypersomnia
NCT07646678 · Recruiting · Phase 2 / Phase 3 · Takeda
Ages 18 to 71
https://clinicaltrials.gov/study/NCT07646678
- 2.
A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 2
NCT07502443 · Recruiting · Phase 3 · Alkermes, Inc.
Ages 18 to 70
https://clinicaltrials.gov/study/NCT07502443
- 3.
A Study to Evaluate the Efficacy and Safety of ALKS 2680 in Adults With Narcolepsy Type 1
NCT07455383 · Recruiting · Phase 3 · Alkermes, Inc.
Ages 18 to 70
https://clinicaltrials.gov/study/NCT07455383
- 4.
A Novel Approach to Manage Symptoms of Narcolepsy and Idiopathic Hypersomnia
NCT07006233 · Recruiting · University of Sydney
Ages 18 and over
https://clinicaltrials.gov/study/NCT07006233
- 5.
A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia
NCT06767683 · Recruiting · Phase 2 / Phase 3 · Alkermes, Inc.
Ages 18 to 70
https://clinicaltrials.gov/study/NCT06767683
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Narcolepsy
Narcolepsy is a chronic neurological condition caused by loss of orexin-producing neurons in the brain, causing excessive daytime sleepiness and cataplexy (sudden muscle weakness triggered by emotion). It is significantly underdiagnosed. Medications can manage symptoms effectively, and orexin-based treatments are in development.
This overview is general information, not an individual medical assessment. Research is selected automatically and may include mismatches. How we select and explain research.
Most Recent Research
Common Questions
What is Narcolepsy?
Narcolepsy is a chronic neurological condition caused by loss of orexin-producing neurons in the brain, causing excessive daytime sleepiness and cataplexy (sudden muscle weakness triggered by emotion). It is significantly underdiagnosed. Medications can manage symptoms effectively, and orexin-based treatments are in development.
How many clinical trials are available for Narcolepsy?
RareWays currently indexes 121 clinical trials for Narcolepsy, of which 27 are actively recruiting. These counts cover indexed trials across countries, not just your country. An Australian site does not necessarily mean that site is recruiting. Check locations, eligibility and current availability with the study team.
Where does the research data for Narcolepsy come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is refreshed automatically every day. All articles and trials link directly to their original sources.
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