Myalgic Encephalomyelitis / Chronic Fatigue Syndrome — Research Summary
Printed from RareWays (rareways.com.au) on 26 July 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Exploring differences in protein cargo of extracellular vesicles from ME/CFS patient plasma compared to healthy controls.
Rydland Anne et al. — Biochemistry and biophysics reports (1 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42375682/
- 2.
Non-invasive electrochemical detection of cortisol in artificial sweat using molecularly imprinted polymer.
Ayankojo Akinrinade George et al. — Talanta (1 September 2026)
https://pubmed.ncbi.nlm.nih.gov/41967225/
- 3.
Shengyang Sanhuo decoction and its disassembled prescriptions improve chronic fatigue syndrome in mice: Insights from lipid metabolism and autophagy.
Li Lingling et al. — Journal of ethnopharmacology (10 August 2026)
https://pubmed.ncbi.nlm.nih.gov/42000004/
- 4.
The efficacy of exercise in patients with myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review and meta-analysis.
Zhao Liping et al. — Journal of psychosomatic research (1 August 2026)
https://pubmed.ncbi.nlm.nih.gov/42000527/
- 5.
Pipeline-optimized machine learning for chronic fatigue syndrome diagnosis: A lightweight, interpretable model using blood biochemical and metabolomic data.
Li Junrong et al. — Computational biology and chemistry (1 August 2026)
https://pubmed.ncbi.nlm.nih.gov/41791269/
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
Myalgic Encephalomyelitis / Chronic Fatigue Syndrome is a complex, chronic disease characterised by profound fatigue that is not improved by rest, post-exertional malaise, and often cognitive impairment and sleep disturbances. It affects an estimated 240,000 Australians. The cause remains under investigation, with recent research identifying immune and neurological abnormalities.
Most Recent Research
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by post-exertional malaise, fatigue and pain. Yet, its underlying biological mechanisms remain poorly understood. Extracellular vesicles (EVs) are nanoparticles carrying biological cargo and are involved in cell-cell communication. Plasma EVs reflect several disease states and may serve as minimally invasive biomarkers. In this exploratory study, we characterized the plasma EV profiles of ME/CFS patients (N = 49) and healthy controls (N = 50), by enriching for EVs by size-exclusion chromatography coupled to high-resolution quantitative proteomics. The ME/CFS patients had significantly higher concentrations of EVs than healthy controls. Among the 424 detected proteins included for analyses, 11 had different levels in EVs from ME/CFS patients. The ME/CFS associated EV proteins appear to mainly originate from erythroid cells, hepatocytes and plasma B cells, based on their tissue expression. Albeit differences in EV protein levels did not withstand correction for multiple testing, our study is the largest to date, thereby encouraging future investigations on the role of EV and its cargo in ME/CFS.
Common Questions
What is Myalgic Encephalomyelitis / Chronic Fatigue Syndrome?
Myalgic Encephalomyelitis / Chronic Fatigue Syndrome is a complex, chronic disease characterised by profound fatigue that is not improved by rest, post-exertional malaise, and often cognitive impairment and sleep disturbances. It affects an estimated 240,000 Australians. The cause remains under investigation, with recent research identifying immune and neurological abnormalities.
How many clinical trials are available for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome?
RareWays currently indexes 223 clinical trials for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome, of which 40 are actively recruiting. Trial availability changes as new studies are registered — check the trials tab for current status.
Where does the research data for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is updated regularly by Rocky, RareWays' automated research engine. All articles and trials link directly to their original sources.
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This information is for general awareness only.
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