Myalgic Encephalomyelitis / Chronic Fatigue Syndrome — Research Summary
Printed from RareWays (rareways.com.au) on 5 April 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Chronic fatigue syndrome: From etiology and mechanism to diagnosis and treatment.
Xu Qing et al. — Journal of psychiatric research (1 May 2026)
https://pubmed.ncbi.nlm.nih.gov/41707618/
- 2.
Proteomic signatures in cerebrospinal fluid and their clinical associations in patients with ME/CFS.
Bragée Björn et al. — Scientific reports (3 April 2026)
https://pubmed.ncbi.nlm.nih.gov/41932997/
- 3.
A Description of Healthcare Utilization in Young Adults with Chronic Overlapping Pain.
Babiloni Alberto Herrero et al. — The Clinical journal of pain (1 April 2026)
https://pubmed.ncbi.nlm.nih.gov/41919472/
- 4.
Pathophysiological mechanisms of fatigue and multidisciplinary management strategies (Review).
Zhou Hong et al. — Experimental and therapeutic medicine (1 April 2026)
https://pubmed.ncbi.nlm.nih.gov/41694112/
- 5.
A preliminary proof-of-concept trial on the effects of ketamine on fatigue: a randomized crossover trial.
Goto Taichi et al. — Pharmacological reports : PR (1 April 2026)
https://pubmed.ncbi.nlm.nih.gov/41569403/
Clinical Trials — Currently Recruiting (Australia)
Ask your doctor whether you or your child may be eligible for any of these trials.
- 1.
Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia
Recruiting — Phase 1 — Disc Medicine, Inc
https://clinicaltrials.gov/study/NCT05320198
- 2.
A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
Recruiting — Phase 3 — Regeneron Pharmaceuticals
https://clinicaltrials.gov/study/NCT07222761
- 3.
AutoInflammatory Disease Alliance Registry (AIDA)
Recruiting — University of Siena
https://clinicaltrials.gov/study/NCT05200715
- 4.
A Real World Effectiveness Study of Pegcetacoplan in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)
Recruiting — Swedish Orphan Biovitrum
https://clinicaltrials.gov/study/NCT05776472
- 5.
A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections
Recruiting — Phase 3 — X4 Pharmaceuticals
https://clinicaltrials.gov/study/NCT06056297
- 6.
An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)
Recruiting — Phase 3 — AstraZeneca
https://clinicaltrials.gov/study/NCT05952557
- 7.
A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions
Recruiting — Phase 3 — Takeda
https://clinicaltrials.gov/study/NCT07422480
- 8.
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
Recruiting — Phase 3 — Pfizer
https://clinicaltrials.gov/study/NCT06758401
- 9.
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
Recruiting — Na — Weill Medical College of Cornell University
https://clinicaltrials.gov/study/NCT04124120
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
Myalgic Encephalomyelitis / Chronic Fatigue Syndrome is a complex, chronic disease characterised by profound fatigue that is not improved by rest, post-exertional malaise, and often cognitive impairment and sleep disturbances. It affects an estimated 240,000 Australians. The cause remains under investigation, with recent research identifying immune and neurological abnormalities.
Most Recent Research
Myalgic encephalomyelitis (ME), commonly known as chronic fatigue syndrome (CFS), is a long-lasting neurological disease. The cause of ME remains uncertain, characterized by unrelenting or recurring fatigue not alleviated by rest. In recent times, CFS incidence has been on the rise annually, showing a tendency towards younger sufferers. Especially post-COVID-19, its prevalence has surged, posing a significant threat to 21st-century health. CFS symptoms are intricate and diverse. Patients typically endure extreme fatigue lasting over six months, accompanied by physical and neuropsychiatric symptoms like sore throat, muscle/joint pain, anxiety, and distress. These severely disrupt daily life and work, heightening illness risks and financial strain. With the unknown etiology, current treatments have limited success and may induce psychological issues such as anxiety and depression. This paper delivers an extensive and thorough overview of the latest developments in the studies concerning the pathogenesis, diagnostic standards, and therapeutic approaches for chronic fatigue syndrome. Integrating and assessing the existing knowledge body related to this field systematically, we aim to facilitate continuous research and gain a deeper understanding of this complex medical problem whose mechanism remains largely unknown. Moreover, valuable insights and practical recommendations for future related treatments and research are also provided.
This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.