Klippel-Trénaunay Syndrome — Research Summary
Printed from RareWays (rareways.com.au) on 24 September 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Klippel—Trenaunay Syndrome: Knowledge Revision and Current Treatment Options
О. Ya. Porembskaya et al. — Journal of Venous Disorders (22 September 2026)
https://doi.org/10.17116/flebo202620031250
- 2.
A novel Doppler ultrasound approach for phenotypic assessment and follow-up of Klippel-Trénaunay syndrome: A retrospective multicenter study.
Li Dan et al. — Phlebology (18 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42759969/
- 3.
Early endovenous laser ablation with 1940-nm wavelength for symptomatic marginal veins in pediatric Klippel-Trenaunay syndrome: A 4-year retrospective cohort study on safety, limb hypertrophy, and quality of life.
Mahmoud Amr Abdelghaffar et al. — Journal of vascular surgery. Venous and lymphatic disorders (4 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42697435/
- 4.
Pulmonary Embolism as the Initial Presentation of Klippel-Trénaunay Syndrome.
Al Ghazawy Ahmed et al. — JACC. Case reports (2 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42446450/
- 5.
Klippel-Trénaunay syndrome presenting with recurrent superficial thrombophlebitis.
Mumoli Nicola et al. — Internal and emergency medicine (2 September 2026)
https://pubmed.ncbi.nlm.nih.gov/42687078/
Clinical Trials — Currently Recruiting (Australia)
Ask your doctor whether you or your child may be eligible for any of these trials.
- 1.
A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)
Recruiting — Phase 2 — Relay Therapeutics, Inc.
https://clinicaltrials.gov/study/NCT06789913
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Klippel-Trénaunay Syndrome
Klippel-Trénaunay syndrome is a rare condition in which blood and lymph vessels do not form normally in one part of the body, usually a leg. It typically causes a port-wine stain on the skin, swollen or varicose veins, lymphatic swelling, and overgrowth of the affected limb. Care is shared between specialists and may include compression garments, sclerotherapy, laser treatment, surgery and targeted medicines, along with pain and mobility support.
Most Recent Research
Klippel—Trenaunay syndrome (KTS) is a congenital disorder caused by somatic genetic mutations with formation of capillary, venous, and lymphatic malformations. KTS is characterized by limb enlargement, its deformation, varicose veins, and port-wine stains on the skin. Persistent embryonic veins and incompetent saphenous veins cause venous reflux and subsequent venous hypertension, leading to severe chronic venous insufficiency symptoms in KTS patients. Deep vein anomalies in KTS accompany superficial vein anomalies in only a relatively small number of patients, making it possible to consider various methods of removing the latter to alleviate venous hypertension. In the majority of patients, endovascular techniques for thermal and non-thermal superficial vein ablation and perforator vein embolization enable a sustained reduction in the severity of disease symptoms without a high risk of postoperative complications. This literature review aims to revise the current concepts of KTS and analyze available publications on the surgical management of this pathology in adults.
Common Questions
What is Klippel-Trénaunay Syndrome?
Klippel-Trénaunay syndrome is a rare condition in which blood and lymph vessels do not form normally in one part of the body, usually a leg. It typically causes a port-wine stain on the skin, swollen or varicose veins, lymphatic swelling, and overgrowth of the affected limb. Care is shared between specialists and may include compression garments, sclerotherapy, laser treatment, surgery and targeted medicines, along with pain and mobility support.
How many clinical trials are available for Klippel-Trénaunay Syndrome?
RareWays currently indexes 9 clinical trials for Klippel-Trénaunay Syndrome, of which 4 are actively recruiting. Trial availability changes as new studies are registered — check the trials tab for current status.
Where does the research data for Klippel-Trénaunay Syndrome come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is updated regularly by Rocky, RareWays' automated research engine. All articles and trials link directly to their original sources.
Get research updates
Monthly email when new findings are published for Klippel-Trénaunay Syndrome.
No spam. Unsubscribe any time. Not medical advice.
This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.