Systemic Lupus Erythematosus — Research Summary
Printed from RareWays (rareways.com.au) on 5 April 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Response to letter regarding variants in the interferon regulatory factor 5 gene confer genetic risk for systemic lupus erythematosus in a Han Chinese population.
Xu Wenqi et al. — Annals of medicine (1 December 2026)
https://pubmed.ncbi.nlm.nih.gov/41841449/
- 2.
Treatment of discoid lupus erythematosus with crisaborole.
Dai Yingying et al. — The Journal of dermatological treatment (1 December 2026)
https://pubmed.ncbi.nlm.nih.gov/41808655/
- 3.
Persistent cutaneous lupus erythematosus: A pathway toward systemic disease?
Wang Qi et al. — Journal of translational autoimmunity (1 June 2026)
https://pubmed.ncbi.nlm.nih.gov/41869391/
- 4.
A novel epigenetic regulation of JAM-A by EZH2-DNMT3A cascade contributes to T cell adhesion via the activation of Rap1a in lupus patients.
Ding Lei et al. — Journal of translational autoimmunity (1 June 2026)
https://pubmed.ncbi.nlm.nih.gov/41815940/
- 5.
GRN and KLRB1 define a shared peripheral-blood transcriptomic signature linking SLE and IPF.
Pang Lijun et al. — Journal of translational autoimmunity (1 June 2026)
https://pubmed.ncbi.nlm.nih.gov/41782635/
Clinical Trials — Currently Recruiting (Australia)
Ask your doctor whether you or your child may be eligible for any of these trials.
- 1.
A PHASE II PROSPECTIVE RANDOMIZED DOUBLE-MASKED CROSSOVER STUDY ASSESSING THE SAFETY & EFFICACY OF RHPRG4 (450 μG/ML RECOMBINANT HUMAN PROTEOGLYCAN 4) COMPARED TO VEHICLE FOR THE TREATMENT OF OCULAR GRAFT-VERSUS-HOST DISEASE (OGVHD)
Recruiting — Phase 2 — Lubris Bio Pty Ltd
https://clinicaltrials.gov/study/NCT07118254
- 2.
Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).
Recruiting — Phase 3 — Novartis Pharmaceuticals
https://clinicaltrials.gov/study/NCT06133972
- 3.
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC
Recruiting — Phase 3 — AstraZeneca
https://clinicaltrials.gov/study/NCT06627647
- 4.
A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE
Recruiting — Phase 1 — AstraZeneca
https://clinicaltrials.gov/study/NCT06897930
- 5.
Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
Recruiting — Phase 3 — Novartis Pharmaceuticals
https://clinicaltrials.gov/study/NCT05827081
- 6.
A PHASE II PROSPECTIVE RANDOMIZED DOUBLE-MASKED CONTROLLED STUDY ASSESSING THE SAFETY & EFFICACY OF RHPRG4 (450 µG/ML RECOMBINANT HUMAN PROTEOGLYCAN 4) COMPARED TO VEHICLE FOR THE TREATMENT OF SJÖGREN'S RELATED DRY EYE DISEASE
Recruiting — Phase 2 — Lubris Bio Pty Ltd
https://clinicaltrials.gov/study/NCT07118241
- 7.
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
Recruiting — Phase 2 — Mirati Therapeutics Inc.
https://clinicaltrials.gov/study/NCT04613596
- 8.
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Recruiting — Phase 1 — Hoffmann-La Roche
https://clinicaltrials.gov/study/NCT04929223
- 9.
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
Recruiting — Phase 1 — AstraZeneca
https://clinicaltrials.gov/study/NCT07201558
- 10.
Clinical Trial to Evaluate Safety, Tolerability, and Pharmacokinetics of SOF-SKN in Healthy Participants
Recruiting — Early Phase 1 — Noxopharm Limited
https://clinicaltrials.gov/study/NCT07072611
- 11.
A Phase III Study to Investigate the Efficacy and Safety of Anifrolumab in Adults With Chronic and/or Subacute Cutaneous Lupus Erythematosus
Recruiting — Phase 3 — AstraZeneca
https://clinicaltrials.gov/study/NCT06015737
- 12.
Validation of the Lupus Low Disease Activity State (LLDAS) in the Asia Pacific Region
Recruiting — Monash University
https://clinicaltrials.gov/study/NCT03138941
- 13.
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
Recruiting — Phase 3 — Stemline Therapeutics, Inc.
https://clinicaltrials.gov/study/NCT06492616
- 14.
A Phase 1/2a Study of DB-2304 in Healthy Adults and SLE Participants
Recruiting — Phase 1 — DualityBio Inc.
https://clinicaltrials.gov/study/NCT06625671
- 15.
A Study to Evaluate the Safety and Activity of SAR448501/DR-0201 in Patients With Autoimmune Rheumatic Diseases
Recruiting — Phase 1 — Sanofi
https://clinicaltrials.gov/study/NCT06647069
- 16.
A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
Recruiting — Phase 2 — Amgen
https://clinicaltrials.gov/study/NCT06570798
- 17.
A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)
Recruiting — Phase 2 — Novartis Pharmaceuticals
https://clinicaltrials.gov/study/NCT06581198
- 18.
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupus Erythematosus
Recruiting — Phase 1 — Cullinan Therapeutics Inc.
https://clinicaltrials.gov/study/NCT06613360
- 19.
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)
Recruiting — Phase 3 — AstraZeneca
https://clinicaltrials.gov/study/NCT06692738
- 20.
A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases
Recruiting — Phase 1 — Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
https://clinicaltrials.gov/study/NCT07115745
- 21.
A Study of LY4298445 in Healthy Participants and Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)
Recruiting — Phase 1 — Eli Lilly and Company
https://clinicaltrials.gov/study/NCT07276958
- 22.
Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus
Recruiting — Phase 3 — AbbVie
https://clinicaltrials.gov/study/NCT05843643
- 23.
ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer
Recruiting — Phase 3 — BioNTech SE
https://clinicaltrials.gov/study/NCT07173751
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Systemic Lupus Erythematosus
Systemic lupus erythematosus (lupus) is a chronic autoimmune disease in which the immune system attacks the body's own tissues, causing inflammation affecting joints, skin, kidneys, and other organs. It predominantly affects women of childbearing age. While there is no cure, a growing range of treatments can manage the condition effectively.
Most Recent Research
This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.