Pulmonary Arterial Hypertension — Research Summary
Printed from RareWays (rareways.com.au) on 5 April 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
The process of developing an HIV disclosure intervention for youth with perinatally acquired HIV: The HIV Empowering Adults' Decisions to Share - UK/Uganda Project (Heads-Up).
Evangeli Michael et al. — Global public health (31 December 2026)
https://pubmed.ncbi.nlm.nih.gov/41800659/
- 2.
Loss of productivity among commercially insured patients with pulmonary arterial hypertension in the United States.
Watzker Anna et al. — Journal of medical economics (1 December 2026)
https://pubmed.ncbi.nlm.nih.gov/41861398/
- 3.
Pulmonary hypertension in dialysis patients: clinical insights from tricuspid regurgitation velocity (TRV)-based echocardiographic criteria.
Koowattanatianchai Sukrisd et al. — Renal failure (1 December 2026)
https://pubmed.ncbi.nlm.nih.gov/41851998/
- 4.
Smoking exposure on diagnosis and survival of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Data from REHAP registry.
Khilzi Karys et al. — Pulmonology (1 December 2026)
https://pubmed.ncbi.nlm.nih.gov/41804599/
- 5.
Pulmonary vasomodulators in adults with repaired pulmonary atresia with ventricular septal defect: Single-center experience and review of literature.
Lipps Kirsten M et al. — International journal of cardiology. Congenital heart disease (1 June 2026)
https://pubmed.ncbi.nlm.nih.gov/41798108/
Clinical Trials — Currently Recruiting (Australia)
Ask your doctor whether you or your child may be eligible for any of these trials.
- 1.
Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)
Recruiting — Phase 1 — Merck Sharp & Dohme LLC
https://clinicaltrials.gov/study/NCT02861573
- 2.
Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)
Recruiting — Phase 3 — Celcuity Inc
https://clinicaltrials.gov/study/NCT06757634
- 3.
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
Recruiting — Phase 3 — UMC Utrecht
https://clinicaltrials.gov/study/NCT02735707
- 4.
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations
Recruiting — Phase 3 — Children's Oncology Group
https://clinicaltrials.gov/study/NCT04293562
- 5.
Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)
Recruiting — Phase 1 — Merck Sharp & Dohme LLC
https://clinicaltrials.gov/study/NCT04938817
- 6.
Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
Recruiting — Phase 3 — University College, London
https://clinicaltrials.gov/study/NCT04685616
- 7.
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
Recruiting — Phase 1 — University of Birmingham
https://clinicaltrials.gov/study/NCT04625907
- 8.
A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
Recruiting — Phase 3 — Bristol-Myers Squibb
https://clinicaltrials.gov/study/NCT06646276
- 9.
Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)
Recruiting — Phase 2 — Merck Sharp & Dohme LLC
https://clinicaltrials.gov/study/NCT05587712
- 10.
A Safety and Pharmacokinetics Study of RC220 Combined With Doxorubicin in Adult Participants With Solid Tumours.
Recruiting — Phase 1 — Race Oncology Ltd
https://clinicaltrials.gov/study/NCT06815575
- 11.
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
Recruiting — Phase 3 — Merck Sharp & Dohme LLC
https://clinicaltrials.gov/study/NCT06717347
- 12.
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
Recruiting — Phase 3 — AstraZeneca
https://clinicaltrials.gov/study/NCT06283966
- 13.
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
Recruiting — Phase 3 — Celgene
https://clinicaltrials.gov/study/NCT06911502
- 14.
Perioperative Durvalumab With Neoadjuvant ddMVAC or Gemcitabine/Cisplatin in Patients With Muscle-invasive Bladder Cancer (NIAGARA-2)
Recruiting — Phase 3 — AstraZeneca
https://clinicaltrials.gov/study/NCT06960577
- 15.
Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours
Recruiting — Phase 3 — University of Sydney
https://clinicaltrials.gov/study/NCT02582697
- 16.
A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT
Recruiting — Phase 2 — Children's Oncology Group
https://clinicaltrials.gov/study/NCT04684368
- 17.
Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
Recruiting — Phase 3 — BioNTech SE
https://clinicaltrials.gov/study/NCT06712355
- 18.
A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma
Recruiting — Phase 2 — National Cancer Institute (NCI)
https://clinicaltrials.gov/study/NCT05691478
- 19.
A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma
Recruiting — Phase 2 — University of Birmingham
https://clinicaltrials.gov/study/NCT05991388
- 20.
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
Recruiting — Phase 3 — Merck Sharp & Dohme LLC
https://clinicaltrials.gov/study/NCT07218029
- 21.
A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients
Recruiting — Na — McMaster University
https://clinicaltrials.gov/study/NCT03127631
- 22.
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
Recruiting — Na — Weill Medical College of Cornell University
https://clinicaltrials.gov/study/NCT04124120
- 23.
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy
Recruiting — Phase 3 — Children's Oncology Group
https://clinicaltrials.gov/study/NCT03959085
- 24.
A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489
Recruiting — Phase 2 — Pfizer
https://clinicaltrials.gov/study/NCT07073820
- 25.
A Study of CS5001 in Patients With Advanced Solid Tumors and Lymphomas
Recruiting — Phase 1 — CStone Pharmaceuticals
https://clinicaltrials.gov/study/NCT05279300
- 26.
IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)
Recruiting — Phase 3 — Immunocore Ltd
https://clinicaltrials.gov/study/NCT06112314
- 27.
A Trial to Learn How Effective and Safe Odronextamab is Compared to Standard of Care for Adult Participants With Previously Treated Aggressive B-cell Non-Hodgkin Lymphoma
Recruiting — Phase 3 — Regeneron Pharmaceuticals
https://clinicaltrials.gov/study/NCT06230224
- 28.
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
Recruiting — Phase 3 — Merck Sharp & Dohme LLC
https://clinicaltrials.gov/study/NCT06966700
- 29.
A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
Recruiting — Phase 2 — Tectonic Therapeutic
https://clinicaltrials.gov/study/NCT06616974
- 30.
Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
Recruiting — Phase 3 — Children's Oncology Group
https://clinicaltrials.gov/study/NCT03067181
- 31.
Better Evidence and Translation for Calciphylaxis
Recruiting — Phase 3 — University of Sydney
https://clinicaltrials.gov/study/NCT05018221
- 32.
A Phase I/II Study of CS2009 in Participants With Advanced Solid Tumors
Recruiting — Phase 1 — CStone Pharmaceuticals
https://clinicaltrials.gov/study/NCT06741644
- 33.
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
Recruiting — Phase 3 — National Cancer Institute (NCI)
https://clinicaltrials.gov/study/NCT06172296
- 34.
A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)
Recruiting — Phase 3 — Amgen
https://clinicaltrials.gov/study/NCT07005128
- 35.
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies
Recruiting — Phase 1 — AstraZeneca
https://clinicaltrials.gov/study/NCT06564038
- 36.
Finding the Optimal Regimen for Mycobacterium Abscessus Treatment
Recruiting — Phase 2 — The University of Queensland
https://clinicaltrials.gov/study/NCT04310930
- 37.
Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017
Recruiting — Phase 3 — Martin Schrappe
https://clinicaltrials.gov/study/NCT03643276
- 38.
High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)
Recruiting — Phase 3 — Gustave Roussy, Cancer Campus, Grand Paris
https://clinicaltrials.gov/study/NCT04221035
- 39.
A Study to Give Treatment Inside the Eye to Treat Retinoblastoma
Recruiting — Phase 2 — Children's Oncology Group
https://clinicaltrials.gov/study/NCT05504291
- 40.
A Personalised Approach Utilising the Frailty Index to Empower Consumers
Recruiting — Na — Princess Alexandra Hospital, Brisbane, Australia
https://clinicaltrials.gov/study/NCT05292989
- 41.
Risk-guided Disease Management Plan to Prevent Heart Failure in Patients Treated With Previous Chemotherapy (REDEEM)
Recruiting — Na — Baker Heart and Diabetes Institute
https://clinicaltrials.gov/study/NCT04962711
- 42.
Nausea and Vomiting in Postoperative Paediatric Patients With Patient-Controlled Analgesia (PCA): Morphine vs Oxycodone
Recruiting — Phase 4 — Murdoch Childrens Research Institute
https://clinicaltrials.gov/study/NCT06186141
- 43.
Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia
Recruiting — Phase 2 — St. Anna Kinderkrebsforschung
https://clinicaltrials.gov/study/NCT01949129
- 44.
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
Recruiting — Phase 3 — Merck Sharp & Dohme LLC
https://clinicaltrials.gov/study/NCT03486873
- 45.
Neoadjuvant Pembrolizumab in Cutaneous Squamous Cell Carcinoma
Recruiting — Phase 2 — Queensland Health
https://clinicaltrials.gov/study/NCT05025813
- 46.
Extension Study for the Port Delivery System With Ranibizumab (Portal)
Recruiting — Phase 3 — Hoffmann-La Roche
https://clinicaltrials.gov/study/NCT03683251
- 47.
Pulmonary Hemodynamics During Exercise - Research Network
Recruiting — Medical University of Graz
https://clinicaltrials.gov/study/NCT03954574
- 48.
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Recruiting — Phase 3 — Colorado Prevention Center
https://clinicaltrials.gov/study/NCT06008197
- 49.
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma
Recruiting — Phase 2 — Children's Oncology Group
https://clinicaltrials.gov/study/NCT06368817
- 50.
A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer
Recruiting — Phase 3 — BioNTech SE
https://clinicaltrials.gov/study/NCT06340568
- 51.
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
Recruiting — Phase 3 — AstraZeneca
https://clinicaltrials.gov/study/NCT06357533
- 52.
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma
Recruiting — Phase 3 — Genmab
https://clinicaltrials.gov/study/NCT06191744
- 53.
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
Recruiting — Phase 3 — AstraZeneca
https://clinicaltrials.gov/study/NCT06677060
- 54.
Novel Treatment of Radiation Associated Dysphagia With Statins
Recruiting — Phase 2 — Peter MacCallum Cancer Centre, Australia
https://clinicaltrials.gov/study/NCT07217938
- 55.
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
Recruiting — Phase 3 — AstraZeneca
https://clinicaltrials.gov/study/NCT07044336
- 56.
A Study Investigating the Change in Metabolism Phenotype in Paediatric, Adolescent & Young Adults With Hodgkin or Non-Hodgkin Lymphoma.
Recruiting — Phase 1 — Murdoch Childrens Research Institute
https://clinicaltrials.gov/study/NCT06383338
- 57.
A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)
Recruiting — Phase 3 — Children's Oncology Group
https://clinicaltrials.gov/study/NCT06401330
- 58.
Study of Safety and Efficacy of Iberdomide (CC-220) and CC-99282 Combined With R-CHOP to Treat Lymphoma
Recruiting — Phase 1 — Celgene
https://clinicaltrials.gov/study/NCT04884035
- 59.
A Study on Hemolytic Disease of the Fetus and Newborn (HDFN) Through Global Registry
Recruiting — Janssen Research & Development, LLC
https://clinicaltrials.gov/study/NCT07194070
- 60.
Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
Recruiting — Phase 3 — Daiichi Sankyo
https://clinicaltrials.gov/study/NCT06578247
- 61.
DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors
Recruiting — Phase 1 — DynamiCure Biotechnology
https://clinicaltrials.gov/study/NCT05785754
- 62.
A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)
Recruiting — Phase 3 — Janssen Research & Development, LLC
https://clinicaltrials.gov/study/NCT05912517
- 63.
A Study to Evaluate Glofitamab Monotherapy and Glofitamab + Chemoimmunotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Mature B-Cell Non-Hodgkin Lymphoma
Recruiting — Phase 1 — Hoffmann-La Roche
https://clinicaltrials.gov/study/NCT05533775
- 64.
A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma
Recruiting — Phase 3 — Regeneron Pharmaceuticals
https://clinicaltrials.gov/study/NCT06091254
- 65.
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
Recruiting — Phase 3 — Novo Nordisk A/S
https://clinicaltrials.gov/study/NCT07207811
- 66.
A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT
Recruiting — Phase 2 — Children's Oncology Group
https://clinicaltrials.gov/study/NCT04322318
- 67.
High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN)
Recruiting — Phase 3 — St. Anna Kinderkrebsforschung
https://clinicaltrials.gov/study/NCT01704716
- 68.
International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia
Recruiting — Phase 3 — University of Birmingham
https://clinicaltrials.gov/study/NCT02724163
- 69.
Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease
Recruiting — The University of Texas Health Science Center, Houston
https://clinicaltrials.gov/study/NCT04005976
- 70.
Safety and Preliminary Efficacy of Pumitamig (BNT327), an Investigational Therapy for Patients With Non-small Cell Lung Cancer in Combination With Chemotherapy as First-line or Second-line Treatment
Recruiting — Phase 2 — BioNTech SE
https://clinicaltrials.gov/study/NCT06841055
- 71.
Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma
Recruiting — Phase 3 — Kite, A Gilead Company
https://clinicaltrials.gov/study/NCT05605899
- 72.
EXtubation Related Complications - the EXTUBE Study (EXTUBE)
Recruiting — University Health Network, Toronto
https://clinicaltrials.gov/study/NCT06442930
- 73.
A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
Recruiting — Phase 1 — Novartis Pharmaceuticals
https://clinicaltrials.gov/study/NCT06649110
- 74.
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Recruiting — Phase 3 — Gilead Sciences
https://clinicaltrials.gov/study/NCT05633654
- 75.
A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)
Recruiting — Phase 3 — National Cancer Institute (NCI)
https://clinicaltrials.gov/study/NCT06124157
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Pulmonary Arterial Hypertension
Pulmonary arterial hypertension is a rare, progressive condition causing high blood pressure in the arteries supplying the lungs, leading to right heart failure. It predominantly affects women. While there is no cure, a growing number of targeted therapies can slow progression and improve symptoms.
Most Recent Research
Sharing one's HIV status with others (onward HIV disclosure) for youth with perinatally acquired HIV (PAH) is often difficult but may assist with challenges associated with living with HIV. We describe the development of an intervention to help HIV-sharing decision-making for UK and Ugandan youth with PAH. The methods included : (1) semi-structured interviews with 50 participants (20 with PAH patients aged 18-25 years, 20 friends, family or partners and 10 professionals), (2) a survey of 57 UK participants with PAH patients aged ≥17, (3) the development of an intervention conceptual model, (4) intervention development, including obtaining intervention feedback from 13 youth with PAH. The survey showed that group (23/57; 40%) and mixed individual and group formats (21/57; 37%), mixed gender groups (52/57; 91%) and peer worker involvement (54/57; 95%) were preferred. The interviews highlighted the importance of overcoming feelings of shame and accepting one's status before sharing, having support to feel confident to share, personal values playing a part in sharing decisions and friends and partners explaining that they had not been educated about HIV until someone had shared their status with them. We describe the finalised intervention, and strengths and limitations of the intervention development process are outlined.Trial registration: ISRCTN Registry, ISRCTN31852047, Registered on 21 January 2019.
This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.