Multiple Sclerosis — Research Summary
Printed from RareWays (rareways.com.au) on 5 April 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Emerging role of cell membrane-coated nanoparticles in targeted therapy for brain disorders.
Kumari Vaishnavi et al. — Biomaterials advances (1 July 2026)
https://pubmed.ncbi.nlm.nih.gov/41880816/
- 2.
RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling.
Baldassarro Vito Antonio et al. — Glia (1 June 2026)
https://pubmed.ncbi.nlm.nih.gov/41934103/
- 3.
Decisive role of brain biopsy in atypical tumefactive demyelinating lesions: A case report.
Bülbül Nazlı Gamze et al. — Radiology case reports (1 June 2026)
https://pubmed.ncbi.nlm.nih.gov/41868457/
- 4.
Pediatric Optic Neuritis: An Update on Diagnosis and Management.
Deyabat Osama Al et al. — Neurologic clinics (1 May 2026)
https://pubmed.ncbi.nlm.nih.gov/41922038/
- 5.
Updates on Imaging Features of Optic Neuritis and Mimicking Syndromes.
Malkawi Lna et al. — Neurologic clinics (1 May 2026)
https://pubmed.ncbi.nlm.nih.gov/41922033/
Clinical Trials — Currently Recruiting (Australia)
Ask your doctor whether you or your child may be eligible for any of these trials.
- 1.
A Study of AZD0120 in Autoimmune Diseases
Recruiting — Phase 1 — AstraZeneca
https://clinicaltrials.gov/study/NCT07295847
- 2.
First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)
Recruiting — Phase 1 — Regeneron Pharmaceuticals
https://clinicaltrials.gov/study/NCT06351592
- 3.
Platform Trial to Assess the Efficacy of Multiple Drugs in Amyotrophic Lateral Sclerosis (ALS)
Recruiting — Phase 3 — Stichting TRICALS Foundation
https://clinicaltrials.gov/study/NCT06008249
- 4.
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
Recruiting — Phase 2 — Celgene
https://clinicaltrials.gov/study/NCT06782490
- 5.
Sapu003 in Advanced mTOR-sensitive Solid Tumors
Recruiting — Phase 1 — SAPU NANO (US) LLC
https://clinicaltrials.gov/study/NCT07369505
- 6.
An Open-label Study to Assess the Safety, Efficacy, and Cellular Kinetics of YTB323 in Relapsing Multiple Sclerosis
Recruiting — Phase 1 — Novartis Pharmaceuticals
https://clinicaltrials.gov/study/NCT06617793
- 7.
Open-label, Multi-center, Phase I/II Study to Assess Safety, Disease Progression and Cellular Kinetics Following YTB323 Administration in Participants With Non-active Progressive Multiple Sclerosis (PMS)
Recruiting — Phase 1 — Novartis Pharmaceuticals
https://clinicaltrials.gov/study/NCT06675864
- 8.
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
Recruiting — Phase 3 — Novartis Pharmaceuticals
https://clinicaltrials.gov/study/NCT07225504
- 9.
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therapy to Ocrelizumab, in Participants With Progressive Forms of Multiple Sclerosis (MS)
Recruiting — Phase 2 — Hoffmann-La Roche
https://clinicaltrials.gov/study/NCT07282574
- 10.
Polysomnographic Titration of Non-invasive Ventilation in Motor Neurone Disease
Recruiting — Na — University of Melbourne
https://clinicaltrials.gov/study/NCT05136222
- 11.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VT7208 in Healthy Participants and MS Patients
Recruiting — Phase 1 — Vidya Therapeutics Inc
https://clinicaltrials.gov/study/NCT07085507
- 12.
Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis
Recruiting — Phase 3 — Celgene
https://clinicaltrials.gov/study/NCT06408259
- 13.
Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
Recruiting — Phase 3 — Novartis Pharmaceuticals
https://clinicaltrials.gov/study/NCT06846281
- 14.
A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE
Recruiting — Phase 3 — Janssen Research & Development, LLC
https://clinicaltrials.gov/study/NCT05702034
- 15.
An Open-label Study of AZD0120 in Adults With Multiple Sclerosis
Recruiting — Phase 1 — AstraZeneca
https://clinicaltrials.gov/study/NCT07224373
- 16.
A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease
Recruiting — Phase 2 — GlaxoSmithKline
https://clinicaltrials.gov/study/NCT05878717
- 17.
Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Diffuse Cutaneous Systemic Sclerosis
Recruiting — Phase 2 — Novartis Pharmaceuticals
https://clinicaltrials.gov/study/NCT06655896
- 18.
Efficacy and Safety Study of Frexalimab (SAR441344) in Adults With Nonrelapsing Secondary Progressive Multiple Sclerosis
Recruiting — Phase 3 — Sanofi
https://clinicaltrials.gov/study/NCT06141486
- 19.
A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease
Recruiting — Phase 3 — Janssen Research & Development, LLC
https://clinicaltrials.gov/study/NCT05923073
- 20.
A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years
Recruiting — Phase 2 — ModernaTX, Inc.
https://clinicaltrials.gov/study/NCT06735248
- 21.
Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)
Recruiting — Biogen
https://clinicaltrials.gov/study/NCT05658497
- 22.
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease
Recruiting — Phase 3 — Hoffmann-La Roche
https://clinicaltrials.gov/study/NCT05271409
- 23.
A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.
Recruiting — Phase 1 — Inventage Lab., Inc.
https://clinicaltrials.gov/study/NCT05620940
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Multiple Sclerosis
Multiple Sclerosis is a chronic autoimmune disease of the central nervous system in which the immune system attacks the myelin sheath covering nerve fibres. It affects approximately 26,000 Australians and is the most common neurological condition in young adults. Symptoms vary widely and can include fatigue, vision problems, numbness, and difficulty walking.
Most Recent Research
Brain disorders, including neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, as well as conditions like multiple sclerosis and ischemic stroke, represent a significant global health burden. These disorders are often marked by progressive neuronal degeneration, cognitive impairment, and motor dysfunction. Effective therapeutic intervention remains a challenge due to the protective but restrictive nature of blood-CNS barriers, particularly the blood-brain barrier (BBB), which limits drug delivery to the brain. Nanotechnology-based drug delivery systems have emerged as promising solutions for addressing these barriers. However, issues such as limited biocompatibility, cytotoxicity, and suboptimal pharmacokinetics still hinder their widespread application. Cell membrane-coated nanoparticles (CMCNPs) offer a novel approach to overcome these challenges. These biomimetic nanocarriers integrate natural cell membranes sourced from red blood cells, platelets, or stem cells, with nanoparticles, enhancing biocompatibility, immune evasion, and BBB penetration. This review provides a comprehensive overview of recent advances in CMCNPs for brain disorders, highlighting their design, fabrication methods, and therapeutic potential. The unique properties of CMCNPs, such as prolonged systemic circulation, targeted drug delivery, and enhanced BBB permeability, make them promising candidates for neuroprotective and theranostic applications.
This information is for general awareness only.
For guidance specific to your situation, please speak with your healthcare team.