RareWays is a research directory. It helps you understand the science. It is not medical advice. Always discuss your care options with your healthcare team.
Coverage: 2020-01-01 onwards, with up to 300 results per query from PubMed and Europe PMC and separate limits on other sources. This is a selected index, not a complete literature search.
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Hirschsprung Disease: Research Summary
Printed from RareWays (rareways.org)
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
TXNRD1-driven enteric glial remodeling promotes neuronal dysfunction in Hirschsprung disease.
Li Yanyi et al., iScience (16 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42866713/
- 2.
Laparoscopic−assisted versus purely transanal Soave procedures for Hirschsprung disease in children aged ≤ 4 years: an age−stratified retrospective study
Jichang Han et al., BMC Pediatrics (16 October 2026)
https://doi.org/10.1186/s12887-026-07872-6
- 3.
Preoperative gut microbial and metabolic signatures associated with postoperative Hirschsprung-associated enterocolitis in short-segment Hirschsprung disease
Zhang M et al. (16 October 2026)
https://europepmc.org/search?query=Preoperative%20gut%20microbial%20and%20metabolic%20signature
- 4.
Comparative of Robotic-Assisted versus Laparoscopic-Assisted Modified Soave Pull-Through with Short Muscular Cuff Anastomosis in Infants Under 3 Months with Classical Hirschsprung Disease.
Wang Bo et al., Journal of pediatric surgery (9 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42854893/
- 5.
Single-nucleus transcriptomics reveals multicellular remodeling beyond the aganglionic segment in Hirschsprung disease
Yuanxiang Qiu et al., Scientific Reports (8 October 2026)
https://doi.org/10.1038/s41598-026-69658-1
Clinical Trials : Australian Sites
Ask your doctor whether you or your child may be eligible for any of these trials. Each has its ID and full eligibility criteria at the link shown.
- 1.
Comparison of a New Non-invasive Device With the Invasive Gold-standard Investigation to Assess Function of the Large Bowel in Children
NCT07789782 · Not yet recruiting · Murdoch Childrens Research Institute
Ages 6 Months to 18
https://clinicaltrials.gov/study/NCT07789782
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Hirschsprung Disease
Hirschsprung disease is a condition present from birth in which nerve cells are missing from the end of the bowel, so stool cannot move through normally. It usually shows up in newborns as constipation, a swollen abdomen or a bowel blockage. Treatment is surgery to remove the affected section of bowel, with ongoing follow-up of bowel function.
This overview is general information, not an individual medical assessment. Research is selected automatically and may include mismatches. How we select and explain research.
Most Recent Research
Hirschsprung disease (HSCR) is characterized by distal intestinal aganglionosis and persistent dysfunction of the enteric nervous system after surgical treatment. Here, we integrated single-cell transcriptomics, network-based virtual perturbation analysis, proteomics, human tissue validation, enteric glial cell assays, neuron-glia co-culture systems, and an Ednrb conditional knockout (cKO) mouse model to investigate TXNRD1-dependent enteric glial remodeling in HSCR. We found that thioredoxin reductase 1 (TXNRD1) enrichment was associated with expansion of an SPP1-high/CXCL9-low enteric glial state and selective ERK/MAPK activation. TXNRD1 overexpression increased oxidative stress, impaired enteric glial migration and neurotrophic support, and induced neuronal dysfunction through suppression of GDNF/GFRα1/RET signaling. TXNRD1 inhibition alleviated HSCR-like phenotypes in Ednrb cKO mice. These findings identify TXNRD1-driven redox-dependent enteric glial remodeling as a mechanism contributing to neuronal dysfunction and HSCR progression.
Common Questions
What is Hirschsprung Disease?
Hirschsprung disease is a condition present from birth in which nerve cells are missing from the end of the bowel, so stool cannot move through normally. It usually shows up in newborns as constipation, a swollen abdomen or a bowel blockage. Treatment is surgery to remove the affected section of bowel, with ongoing follow-up of bowel function.
How many clinical trials are available for Hirschsprung Disease?
RareWays currently indexes 36 clinical trials for Hirschsprung Disease, of which 3 are actively recruiting. These counts cover indexed trials across countries, not just your country. An Australian site does not necessarily mean that site is recruiting. Check locations, eligibility and current availability with the study team.
Where does the research data for Hirschsprung Disease come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is refreshed automatically every day. All articles and trials link directly to their original sources.
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