ICD M61.11ORPHA:337FOP

Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic condition caused by ACVR1 mutations, causing muscles, tendons, and ligaments to progressively turn into bone. Any injury or surgery triggers new bone formation. Palovarotene, the first approved treatment, reduces the volume of new heterotopic bone.

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26 March 2026
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For guidance specific to your situation, please speak with your healthcare team.