ICD M61.11ORPHA:337FOP

Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic condition caused by ACVR1 mutations, causing muscles, tendons, and ligaments to progressively turn into bone. Any injury or surgery triggers new bone formation. Palovarotene, the first approved treatment, reduces the volume of new heterotopic bone.

481
Articles
21
Trials (7 AU)
Updated
26 March 2026
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Common Questions

What is Fibrodysplasia Ossificans Progressiva?

Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic condition caused by ACVR1 mutations, causing muscles, tendons, and ligaments to progressively turn into bone. Any injury or surgery triggers new bone formation. Palovarotene, the first approved treatment, reduces the volume of new heterotopic bone.

How many clinical trials are available for Fibrodysplasia Ossificans Progressiva?

RareWays currently indexes 21 clinical trials for Fibrodysplasia Ossificans Progressiva, of which 4 are actively recruiting. Trial availability changes as new studies are registered — check the trials tab for current status.

Where does the research data for Fibrodysplasia Ossificans Progressiva come from?

RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is updated regularly by Rocky, RareWays' automated research engine. All articles and trials link directly to their original sources.

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This information is for general awareness only.

For guidance specific to your situation, please speak with your healthcare team.