Eosinophilic Oesophagitis — Research Summary
Printed from RareWays (rareways.com.au) on 25 July 2026
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
Urban Residency is Independently Associated With Allergic Phenotype and Inflammatory Changes in Eosinophilic Esophagitis.
Muftah Mayssan et al. — Journal of clinical gastroenterology (1 August 2026)
https://pubmed.ncbi.nlm.nih.gov/42008647/
- 2.
Detergent-Containing Toothpaste Decreases Esophageal Mucosal Impedance and Alters Salivary Properties in Humans.
Wright Benjamin L et al. — Allergy (3 July 2026)
https://pubmed.ncbi.nlm.nih.gov/42397127/
- 3.
Point-of-Care Esophageal Mucosal Impedance Testing for Diagnosing GERD and EoE.
Vaezi Michael F — Gastroenterology & hepatology (1 July 2026)
https://pubmed.ncbi.nlm.nih.gov/42389323/
- 4.
Eosinophilic Esophagitis and Autoimmune Thyroid Disease: A Population-Based Matched Cohort Study.
Bozorg Soran R et al. — United European gastroenterology journal (1 July 2026)
https://pubmed.ncbi.nlm.nih.gov/42383463/
- 5.
Safety of dupilumab use during pregnancy: A composite evaluation of pregnancy outcomes.
Ventura Frank L et al. — Allergy and asthma proceedings (1 July 2026)
https://pubmed.ncbi.nlm.nih.gov/42343498/
Clinical Trials — Currently Recruiting (Australia)
Ask your doctor whether you or your child may be eligible for any of these trials.
- 1.
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Recruiting — Sanford Health
https://clinicaltrials.gov/study/NCT01793168
- 2.
A Trial to Evaluate EP-104GI in Adults With Eosinophilic Esophagitis (EoE).
Recruiting — Phase 1 — Eupraxia Pharmaceuticals Inc.
https://clinicaltrials.gov/study/NCT05608681
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Eosinophilic Oesophagitis
Eosinophilic Oesophagitis is a chronic immune-mediated condition in which a type of white blood cell (eosinophil) accumulates in the oesophagus, causing inflammation, swallowing difficulties, and food impaction. Its prevalence is rapidly rising in Australia. It is strongly associated with food allergies and atopic conditions.
Most Recent Research
GOALS: To identify clinical features associated with geographic residency in patients with eosinophilic esophagitis (EoE). BACKGROUND: Prior studies on the geographic distribution of eosinophilic esophagitis (EoE) have focused on disease prevalence. Geographic and environmental factors may impact the clinical characteristics and phenotypes of EoE, although data remain limited. STUDY: This was a cross-sectional study of consecutive patients residing in Massachusetts with newly diagnosed EoE (≥15 eosinophils/hpf). Patients' residency settings were classified as urban or nonurban based on the 2020 US Census and residential zip codes. Clinical, endoscopic, and histologic variables were recorded. EoE patients in urban versus nonurban settings were compared using the student t test or the Fisher exact test for univariate analyses. Multivariable logistic regression was performed to identify the independent association between urban residency and comorbid atopic conditions, the inflammatory endotype, and the fibrostenotic endotype. RESULTS: Six hundred eighty-three EoE patients were included, with 136 (20.0%) urban and 547 (80%) nonurban residents. Urban patients had higher rates of atopy (63.2% vs. 51.8%, P =0.02), severe food/environmental allergies (17.7% vs. 8.3%, P =0.002), and inflammatory findings endoscopic (43.4% vs. 27.8%, P =0.0006). On multivariable analysis, atopy (OR=1.57, CI: 1.02-2.40, P =0.04), severe food/environmental allergies (OR=1.99, CI: 1.09-3.63, P =0.02), and inflammatory findings (OR=1.90, CI: 1.22-2.94, P =0.004) remained independently associated with urban residency. CONCLUSIONS: Urban residency is independently associated with severe food/environmental allergies and inflammatory endoscopic findings at EoE diagnosis, suggesting increased allergic phenotype and active inflammation at presentation. Allergen exposure, particularly indoors, and social determinants may be contributory factors. Environmental considerations, such as geographic residency, may impact EoE disease presentation, activity, and outcome.
Common Questions
What is Eosinophilic Oesophagitis?
Eosinophilic Oesophagitis is a chronic immune-mediated condition in which a type of white blood cell (eosinophil) accumulates in the oesophagus, causing inflammation, swallowing difficulties, and food impaction. Its prevalence is rapidly rising in Australia. It is strongly associated with food allergies and atopic conditions.
How many clinical trials are available for Eosinophilic Oesophagitis?
RareWays currently indexes 176 clinical trials for Eosinophilic Oesophagitis, of which 36 are actively recruiting. Trial availability changes as new studies are registered — check the trials tab for current status.
Where does the research data for Eosinophilic Oesophagitis come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is updated regularly by Rocky, RareWays' automated research engine. All articles and trials link directly to their original sources.
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This information is for general awareness only.
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