RareWays is a research directory. It helps you understand the science. It is not medical advice. Always discuss your care options with your healthcare team.
Coverage: 2020-01-01 onwards, with up to 300 results per query from PubMed and Europe PMC and separate limits on other sources. This is a selected index, not a complete literature search.
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Cold Agglutinin Disease: Research Summary
Printed from RareWays (rareways.org)
For general awareness only. Not medical advice. Discuss all care options with your healthcare team.
5 Most Recent Research Articles
- 1.
A Cold and Viscous Clue: Waldenström Macroglobulinemia Presenting With Secondary Cold Agglutinin Syndrome and Hyperviscosity Syndrome
Fukai L. Chuang et al., Cureus (18 October 2026)
https://doi.org/10.7759/cureus.118118
- 2.
From Asymptomatic Myeloperoxidase-Antineutrophil Cytoplasmic Antibody (MPO-ANCA) Seropositivity to Crescentic Glomerulonephritis and Cold Agglutinin Disease Following Chlamydia Infection: A Second-Hit Hypothesis
Hassan Abdelwahab et al., Cureus (17 October 2026)
https://doi.org/10.7759/cureus.118071
- 3.
Myelodysplastic Syndrome With Isolated del(5q) Coexisting With Cold Agglutinin Disease Presenting as Unexplained Hyperbilirubinemia
Madison N Sheppard et al., Cureus (11 October 2026)
https://doi.org/10.7759/cureus.117773
- 4.
Repeated red-cell auto-agglutination on peripheral smear: A clue to cold agglutinin disease presenting with rapidly progressive multifocal digital gangrene.
Garai Sourav et al., QJM : monthly journal of the Association of Physicians (8 October 2026)
https://pubmed.ncbi.nlm.nih.gov/42847666/
- 5.
Pattern of T-Lymphocyte Subpopulation in Patients with Cold Agglutinin Disease
P. I. Vasilchenkova et al., Clinical oncohematology (1 October 2026)
https://doi.org/10.21320/2500-2139-2026-19-4-472-478
Clinical Trials : Australian Sites
Ask your doctor whether you or your child may be eligible for any of these trials. Each has its ID and full eligibility criteria at the link shown.
- 1.
An Open-label Study of Povetacicept in Participants With Autoimmune Cytopenias (RUBY-4)
NCT05757570 · Completed · Phase 1 / Phase 2 · Alpine Immune Sciences Inc, A Subsidiary of Vertex
Ages 18 and over
https://clinicaltrials.gov/study/NCT05757570
- 2.
A Study to Assess the Efficacy and Safety of BIVV009 (Sutimlimab) in Participants With Primary Cold Agglutinin Disease Without A Recent History of Blood Transfusion
NCT03347422 · Completed · Phase 3 · Bioverativ, a Sanofi company
Ages 18 and over
https://clinicaltrials.gov/study/NCT03347422
- 3.
A Study to Assess the Efficacy and Safety of BIVV009 (Sutimlimab) in Participants With Primary Cold Agglutinin Disease Who Have a Recent History of Blood Transfusion (Cardinal Study)
NCT03347396 · Completed · Phase 3 · Bioverativ, a Sanofi company
Ages 18 and over
https://clinicaltrials.gov/study/NCT03347396
Source: RareWays research directory. Data from PubMed, Europe PMC, OpenAlex, ClinicalTrials.gov.
Always verify information with your healthcare team before making any decisions about your care.
Cold Agglutinin Disease
Cold agglutinin disease is a rare autoimmune condition in which antibodies attach to red blood cells at cool temperatures and cause them to clump and break down. This leads to anaemia, tiredness, dark urine and painful bluish discolouration of the fingers, toes and nose in the cold. Management includes keeping warm, avoiding cold exposure, and medicines that reduce the immune attack or complement activity. Transfusions may be needed.
This overview is general information, not an individual medical assessment. Research is selected automatically and may include mismatches. How we select and explain research.
Most Recent Research
Common Questions
What is Cold Agglutinin Disease?
Cold agglutinin disease is a rare autoimmune condition in which antibodies attach to red blood cells at cool temperatures and cause them to clump and break down. This leads to anaemia, tiredness, dark urine and painful bluish discolouration of the fingers, toes and nose in the cold. Management includes keeping warm, avoiding cold exposure, and medicines that reduce the immune attack or complement activity. Transfusions may be needed.
How many clinical trials are available for Cold Agglutinin Disease?
RareWays currently indexes 16 clinical trials for Cold Agglutinin Disease, of which 1 is actively recruiting. These counts cover indexed trials across countries, not just your country. An Australian site does not necessarily mean that site is recruiting. Check locations, eligibility and current availability with the study team.
Where does the research data for Cold Agglutinin Disease come from?
RareWays aggregates research from PubMed, Europe PMC, OpenAlex, and ClinicalTrials.gov. Data is refreshed automatically every day. All articles and trials link directly to their original sources.
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